Drug metabolism Flashcards
1
Q
Why is drug metabolism necessary?
A
We make relatively lipid-soluble drugs so they can pass over membranes
The body needs to make them less lipid-soluble in order to excrete them.
2
Q
What are the two main Phases of drug metabolism?
A
Phase 1: introduces a reactive group to the drug to increase its polarity
Phase 2: adds a water-soluble conjugate to the reactive group
3
Q
A
