Intro to Pharm Flashcards

1
Q

O.D

A

right eye

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2
Q

O.S.

A

left eye

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3
Q

O.U.

A

both eyes

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4
Q

A.D.

A

right ear

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5
Q

A.S.

A

left ear

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6
Q

A.U.

A

both ears

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7
Q

gtts

A

drops

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8
Q

Dosage formula

A

d/h times q

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9
Q

Pharmacokinetics

A

Time

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10
Q

Pharmacodynamics

A

Effect

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11
Q

I Tsp

A

5 mls

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12
Q

1 tablespoon

A

3 tsps so 15 mls

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13
Q

Therapeutic window

A

MEC/MTC

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14
Q

functional antagonism

A

2 agonists with different receptors to produce OPPOSITE effects

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15
Q

Schedule 2 drugs

A

No phone rx
No refills
abuse risk is high

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16
Q

Schedule 3 drugs

A

New Rx every 6 months (5 refills)

moderate/low abuse potential

17
Q

Schedule 4 drugs

A

New Rx every 6 months (5 refills)

LOW abuse potential

18
Q

Full agonists

A
  • full activation of receptors
  • produce maximal pharmacological effect when all receptors are activated
  • maximal intrinsic activity
19
Q

Partial agonists

A
  • produce a submaximal pharmacological effect when all receptors are occupied
  • intrinsic efficacy varies depending on the drug
20
Q

Inverse agonists

A
  • produce an effect opposite to a full or partial agonist
  • decrease receptor signaling
  • decrease response @ receptors with a significant level of receptor activity
21
Q

Pharmacologic antagonism

A

action at the same receptor

22
Q

Chemical antagonism

A

one makes the other drug unavailable

23
Q

physiologic antagonism

A

occurs between endogenous pathways regulated by DIFFERENT receptors

24
Q

Competitive antagonism

A

NO change in Emax

Agonist is increase in EC50

25
Q

Non-Competitive antagonism

A

EC50 is no change

Agonist emax decreases

26
Q

Graded Response

A

How much

27
Q

Quantal response

A

all or none, yes or no

–requires a pre-defined response ie. 10% reduction in BP

28
Q

Non-cumulative quantal dose response curve

A

number of individuals responding at a dose of a drug and only at that dose

29
Q

ED50

A

median effective dose
dose at which 50% of people shows a response to a drug
lower the ED50=more potent

30
Q

Cumulative quantal dose response curve

A

number of individuals responding at a dose of a rug and at all doses LOWER than that dose

31
Q

TD50

A

median toxic dose

32
Q

LD50

A

median lethal dose

33
Q

Therapeutic index

A

TD50/ED50

-higher TI is a safer drug

34
Q

Drug Targets

A
Membrane receptors
Nuclear receptors
Ion channels
Transport Proteins
Enzymes