Intro to Microbiology Flashcards
4 Main Categories of microorganisms
bacteria
fungi
protists + helminths
viruses
Field of Microbiology
field encompassing the study of microorganisms and viruses
X-linked severe combined immunideficiency syndrome (SCID) or “Bubble boy disease”
-X-SCID- a mutation in a single gene disables the body’s ability to fight infection
-individuals with disease die at early age due to severe infection
David Vetter lives in germ free container
Bacteria
single celled, small, relatively simple
adopt a variety of shapes depending on the species (Cocci: spheres, Bacilli: cylendars , Spirochete: snakes)
No nucleus, ER, or membrane bound organelles
The layers of Bacteria
Cytoplasm
Plasma membrane: surface used for respiration
Cell Wall: prevents lysis when water is absorbed
Capsule: Slimy layer of Carbohydrate that protects the bacterium from the immune system
Fungi
Simple eukaryotes that gain energy by digesting and absorbing plant or animal matter
tough cell wall
Hyphal fungi
cells grow in groups of long chains called mycelium (molds,shroooooms)
Yeasts
cells grow as round or oblong sheres
Parasites
disease causing protists and helminths
Protists
single celled
eukaryotes
elaborate apparatuses used for locomotion (flagella, cillia, undulating membrane)
many have an intricate complex life cycle involving several hosts
most include an insect vector that spreads the disease
Helminths
Multicellular
Eukaryotic
most have a complex life cycle that humans are only a small part of
most require poor sanitation and impoverish living conditions
rare in wealthy regions of the world
Viruses
obligate intracellular parasites
not considered living (not cells)- depend on host for replication
Structure of Viruses
Surface glycoprotein (spike protein) Envelope: lipid bilayer membrane Protein coat (capsid): surrounds and protects genome Nucleic Acid (genome)
Viral replication cycle
- Attachment of host cell via surface glycoprotein
- fusion of the viral envelope with the host cell plasma membrane and release of viral nucleic acid into host cell cytoplasm
- replication of viral nucleic acid
- expression of viral proteins
- assembly of new viral particles at the plasma membrane
- release of progeny virus from the infected cell