Intro to Cardiovascular/Renal Pharmacology

Question 1

M1 receptor (type, location, result of ligand binding)

Answer 1

cholinergic
CNS neurons, sympathetic postganglionic neurons, some presynaptic sites
Forms IP3 and DAG, increases intracellular calcium

Question 2

M2 receptor (type, location, result of ligand binding)

Answer 2

cholinergic
myocardium, smooth muscle, some presynaptic sites
opens K+ channels, inhibits adenylyl cyclase
(Gi, dephosp Ca2+channels, phosph K+ channels, all presynaptic)

Question 3

M3 (type, location, result of ligand binding)

Answer 3

cholinergic
exocrine glands, vessels (smooth muscle and endothelium)
Forms IP3 and DAG, increases intracellular Ca2+

Question 4

Nicotinic N (type, location, result of ligand binding)

Answer 4

cholinergic
postganglionic neurons, some presynaptic cholinergic terminals
opens Na+, K+ channels, depolarizes

Question 5

Nicotinic M (type, location, result of ligand binding)

Answer 5

cholinergic
skeletal muscle neuromuscular endplates
opens Na+, K+ channels, depolarization

Question 6

Alpha 1 (type, location, result of ligand binding)

Answer 6

adrenoreceptor
postsynaptic effector cells, esp. smooth muscle
forms IP3 and DAG, increased intracellular Ca2+

Question 7

Alpha 2 (type, location, result of ligand binding)

Answer 7

adrenoreceptor
presynaptic adrenergic nerve terminals, platelets, lipocytes, smooth muscle
INHIBITS adenylyl cyclase, decreased cAMP

Question 8

Beta 1 (type, location, result of ligand binding)

Answer 8

adrenoreceptor
postsynaptic effector cells, esp heart, lipocytes, brain, presynaptic adrenergic and cholinergic receptors
stimulates adenylyl cyclase, increased cAMP

Question 9

Beta 2 (type, location, result of ligand binding)

Answer 9

adrenoreceptor
postsynaptic effector cells, esp smooth muscle and cardiac muscle
stimulates adenylyl cyclased and increased cAPM

Question 10

Beta 3 (type, location, result of ligand binding)

Answer 10

adrenoreceptor
postsynaptic effector cells, esp lipocytes
stimulates adenylyl cyclase and increased cAMP

Question 11

D1 (DA1), D5 (location, result of ligand binding)

Answer 11

brain, effector tissues, esp smooth muscle of renal vascular bed
stimulates adenylyl cylcase and increased cAMP

Question 12

D2 (DA2) (location, result of ligand binding)

Answer 12

brain, effector tissues esp smooth muscle; presynaptic nerve terinals
inhibits adenylyl cyclase; increased potassium conductance

Question 13

D3 (location, result of ligand binding)

Answer 13

brain

inhibition of adenylyl cyclase

Question 14

D4 (location, result of ligand binding)

Answer 14

brain, cardiovascular system

inhibition of adenylyl cyclase