Intro To Cardiovascular And Pulmonary PT Flashcards
Oxygen Consumption
VO2
Oxygen Delivery
DO2
Arterial O2 x CO
DO2
(ArterialO2-venousO2)xCO
VO2
Oxygen extraction ration
Consumption / delivery
VO2/DO2
OER
Is DO2 is based on the demands of the tissues…
At rest, DO2 is _____ greater than the actual demand
3-4x
_____O2 is transported in combination with hemoglobin
98%
O2 binds to ______ on the hemoglobin molecule
Heme
An imbalance between intra and extra vascular fluid can impact _____ which in turn impacts the function of _____
Electrolytes
Organs
Steps in O2 transport
- Air quality
- Airways
- Lungs and chest wall
- Diffusion
- Perfusion
- Myocardial function
- Peripheral Circulation
- Tissue Extraction & Utilization of Oxygen
- Return of partially saturated blood & CO2 to lungs
Composition of air
79% Nitrogen
21% O2
.03% CO2
What happens to alveoli in dry environments
Loss of mucus covering, erosion, and infection
Mechanics of chest wall during inspiration
External intercostals - elevate ribs
Diaphargm - depress inferior wall of the thoracic cavity
Though expiration is a passive process, if muscles are used, what are they and their mechanisms?
Internal intercostals - compress and lower ribs
Abdominals - compress the abdominal cavity which elevates the abdominal organs and passively elevates the diaphragm
Diffusion
Transfer of oxygen from alveolar sacs to pulmonary circulation
5 things diffusion based on
- SA of alveolar capillary membrane
- Diffusing capacity of alveolar-capillary membrane
- Pulmonary capillary blood volume
- Ventilation/perfusion ratio
- Transit time of blood in alveolar capillary membrane
Amount of o2 that diffuses across alveolar-capillary membrane varies directly with ____ and inversely with _____
SA
Thickness
Cardiac output components
Preload,force,rate of contraction,after load
Cardiac measures of impairment
HR and Ejection Fraction
Inotropic effect of heart
Force of contraction
Chronotropic effect of cardiac output
Rate of contraction
Large vessels contain
Elastic and connective tissue
Medium to small vessels
Have more smooth muscle
_______ regulate blood flow through regional vascular beds
Arterioles
Intracellular PO2 averages _____
23 mmHg
Pressure needed for cell metabolism
3 mm Hg
OER at rest
23%
T/F Rate of O2 extraction is regulated by availability
FALSE - it is regulated by demand
Last step of O2 transport
Return of partially desaturated blood and CO2 to the lungs
Myocardial infarction affects which step
Myocardial function
GXT
Graded Exercise Test