INTRO TO BLOOD Flashcards
what is haematopoeisis
the production of blood cells
where are the main sites of haematopoeisis in embryos
yolk sac then liver then marrow
spleen 3rd-7th month
where are the main sites of haematopoeisis at birth
mostly bone marrow, liver and spleen when needed
where are the main sites of haematopoeisis in adulthood
bone marrow of the skull, ribs, sternum, pelvis, proximal femur
(axial skeleton)
what the is difference between long term stem cells and short term stem cells
long term stem cells will continue to produce more stem cells indefinitely whereas short-term stem cells can only produce cells for a certain period of time
what is a reticulocyte
red blood cell with no nucleus but with RNA
what type of cell produces platelets
megakaryocyte
what are the different types if granulocytes
eosinophils
basophils
neutrophils
describe structural features of neutrophils
segmented nucleus
neutral staining granules
what is the function of neutrophils
phagocytosis
attract other immune cells
describe structural features of eosinophils
usually bilobed nucleus
bright orange/red staining granules
what is the function of eosinophils
fight parasitic infections
involved in hypersensitivity
often elevated in allergic conditions
describe structural features of basophils
large deep purple granules obscuring nucleus
what is the function of basophils
mediates hypersensitivity reactions
Fc receptors bind IgE
granules contain histamine
what type of cell do monocytes develop into
macrophages
