Intro to Bio-molecules Flashcards

1
Q

define atoms

A

‘incapable of being divided’

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2
Q

define (Bio/macro) Molecules

A

two or more atoms

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3
Q

define cells

A

smallest living units

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4
Q

define tissue

A

similar cells with common function

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5
Q

define organs

A

two or more tissue types

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6
Q

define organ system

A

cooperative group of organs

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7
Q

define ionic bonding

A

The electrostatic attraction between oppositely charged ions e.g. NaCl

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8
Q

define covalent bonds

A

sharing of electrons e.g. CH4

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9
Q

what does equal sharing of electrons give in covalent bonds

A

non polar bond e.g. CH4

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10
Q

what does unequal sharing of electrons give in covalent bonds

A

polar bond e.g. water

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11
Q

describe hydrogen bonds

A

-hydrogen that is covalently attached to an electronegative atom forms attraction with another v electronegative atom
-they are directional bonds so donor hydrogen and acceptor have to be in same plane e.g. DNA nucleotides
-H bonds are important for DNA and 2° protein structure

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12
Q

describe electrostatic forces

A

-oppositely charged groups attract each other
-amino acids can be ionised and can have interactions between them
-weakened by water and salts becasue they are charged so will compete for electrostatic attraction
-charge on amino acids change according to pH
-this force forms between enzymes and substrate

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13
Q

Describe Van der Waals forces

A

-non specific attraction
-transient asymmetry of electron distribution induces the same in other atoms and an attraction occurs bw the two
-Weak but significant when a number can form at close distance

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14
Q

describe the bonds in water

A

-Biologically important- solvent for large array of molecules
-Electrically polar bc +ve H and -ve O
-Hydrogen bonds- highly cohesive
-Weakens electrostatic & hydrogen bonds
-Nonpolar groups/molecules cluster in water – hydrophobic attractions
-Water-free microenvironments needed for polar reactions bc water will interfere w electrostatic and hydrogen bonds

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15
Q

give polymer for fatty acid

A

Diglyceride, Triglyceride

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16
Q

give polymer for monosaccharide

A

Polysaccharide

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17
Q

give polymer for amino acid

A

protein

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18
Q

give polymer for nucleotide

A

nucleic acid (dna, rna)

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19
Q

describe lipids

A

-structurally diverse
-insoluble in water
-do not form large polymers bc no end to end bonding

20
Q

what are the functions of lipids?

A

Cell membranes (phospholipids)
Storing energy
Insulation, protection & absorbing shocks
Controlling cell activity (steroid hormones)

21
Q

what are fatty acids?

A

long chain carbon molecules which can be saturated or unsaturated

22
Q

what is a triglyceride?

A

a neutral fat made up of glycerol (sugar alcohol) and three fatty acids

23
Q

what is a phospholipid?

A

lipids made of glycerol, phosphate and two fatty acids (one FA replaced with phosphate)

24
Q

what is a sterol?

A

Cholesterol, steroid hormones

25
what is the structure of sterol
overlapping C-H rings
26
why is sterol considered to be lipids?
because they are hydrophobic
27
describe Low density lipoprotein (LDL)
Lipoprotein that carries fatty acids & cholesterol around the body High levels associated with the development of atherosclerosis (thickening or hardening of the arteries)
28
what are carbohydrates?
sugars and polymers of sugars
29
what are the functions of carbohydrates?
-short term energy source -make structural materials e.g. cellulose -act as molecular tags - glycosylation -contribute to structure of nucleotides
30
structure of carbohydrates and examples
Monosaccharides- five or six sided ring e.g. glucose Disaccharide e.g. sucrose Polysaccharide e.g. starch
31
what are proteins?
Amino acids linked by peptide bonds Most abundant & diverse bio-molecule in cells
32
what are the functions of proteins?
-structure, muscles made of actin and myosin, hair -cell transport -contraction -signalling -enzymes -cell attachment
33
Protein structure
Polypeptides of Amino acids (20) Peptide bonds Complicated structures (Primary, secondary, tertiary, quaternary)
34
describe collagen
Most abundant protein in the body Support for tissues, skin etc. Dentin & bone are mineralised collagen
35
how does collagen structure relate to function
Triple, cross-linked helix
36
describe nucleotides
a nitrogenous base, a phosphate group, and a pentose sugar C, N & O ring with 5 carbon sugar and phosphate
37
what is the function of nucleotides?
to store information needed to control and build cells
38
name the two main types of nucleic acids
Deoxyribonucleic acid (DNA) Ribonucleic acid (RNA) messenger, transfer, ribosomal, viral
39
describe DNA
Double helix, A, G (Purine), T, C (pyrimidines) Storage of information in the nucleus
40
describe RNA
single stranded, A, G, U, C nucleotides Made in the nucleus & mRNA transported
41
describe Amelogenesis imperfecta (AI)
Amelogenesis = enamel formation Teeth discoloured and susceptible to cavities & wear Mutations in several genes including those coding for ameloblastin & enamelin
42
describe ATP
Adenosine triphosphate (ATP) -made up of ribose sugar, adenine base and phosphate chain -stores energy for catabolic and anabolic reactions
43
describe nadh
Nicotinamide adenine dinucleotide (NADH) Principle e- donor in respiratory chain Recycled
44
why is RNA easy to degrade?
because it is single stranded
45
what are the functions of biomolecules?
-molecular switch -proteins take part in pathways that create a signal -molecular motors e.g. flagella/cilia -sources of energy e.g. ATP -transport e.g. Hb -information store eg. DNA -antibodies/enzymes
46
map to memorise