Intro Flashcards
Key Features: Innate Immunity
Broad Specificity for structures shared by groups of related microbes Limited (germline-encoded) no memory Nonreactive to self
Key Features: Adaptive Immunity
Specialized
Specificity for antigens of microbes and nonmicrobial antigens
Very Large Diversity (Receptors orduced by somatic recombination of gene segments)
Has memory
Nonreactive to self (ideal workd)
Active Immunity
Get infected or vaccinated and make antibodies
Passive Immunity
Plasma (serum) transfussion to pass antibodies from immune individual to niave individual
Humoral Immunity
type of Adaptive Immunity:
Extracellular Microbes interact with B-Cells. They release their Receptors bound to the microbe, transported by the serum.
Function: Block infections and eliminate extracellular microbes
Cell-mediated Immunity
Type of Adaptive Immunity: Two Pathways
1. Phagocytosed microbes in macrophage, Helper T-cell comes along and activates the macrophage.
Function: Activate Macrophages to kill phagocytosed microbes
- Intracellular Microbes (virus) replicating within the infected cell, Cytotoxic T-cell comes along and binds to the infected cell. Marks it for apoptosis (phagocytosis)
Function: Kill infected cells, eliminate reservoirs of infection