Intro Flashcards
What is the lifespan of erythrocytes in the blood?
120 days
What is the lifespan of thrombocytes in the blood?
10-12 days
What is the lifespan of neutrophils in the blood?
3-5 hours, then migrate to tissue
What is the function of colony-stimulating factors (CSF)?
Drives neutrophil production
What is the function of erythropoietin (EPO)?
Drives RBC production
What is the function of thrombopoietin (TPO)?
Drives platelet production
Hematopoietic stem cells differentiate into what types of cells?
All blood cells
Mesenchymal stem cells differentiate into what types of cells?
Osteoblasts, chondrocytes, myocytes, endothelial cells and adipocytes (“support” cells for hematopoiesis)
What is asymmetric division?
Division of a stem cell into a differentiated progenitor cell and another stem cell for self renewal
What is the role of mesenchymal stem cells in hematopoiesis?
Creation of the bone marrow microenvironment
What are the three constituents of the bone marrow microenvironment?
Stromal cells, extracellular matrix, and regulatory proteins
What type of bone do you find in bone marrow?
Trabecular bone
What is microenvironment specificity?
Unique niches in bone marrow microenvironment for the development of individual lineages
What are the constituents of the proteinaceous “soup” of the bone marrow?
Regulatory factors, adhesion molecules, autostimulatory factors, and osteogenesis-inducing factors
What is myeloperoxidase cytochemical stain (MPO) used for?
Determining
