Intro

Question 1

What is the medical mycology
And what is fungi?

Answer 1

Is the study of fungus organisms that cause disease in human
Fungi is a group of simple cells that have no chlorophils

Question 2

What is the fungus ?

Answer 2

1-fungus are not plants
2-Eukaryotic structures
2-larger and more complex than bacteria
4-Reproduce by spores
5-most of the species are harmless

Question 3

Nutritional adaptation of fungus:

Answer 3

1-grows better in pH 5 which is acidic
2-almost All molds are aerobic, Yeasts are anaerobic
3-Require less nitrogen than bacteria to grow
4-fungus are resistant to high osmotic pressure
5-can break down complex carbohydrates

Question 4

Classification of fungi by morphology:

Answer 4

1/Yeast
.single cellular
.Elongated to form a chain of cells called pseudohyphae
.Reproduce by budding
2/Molds
! Multicellular
!made of filaments that stacked together from end to end
! Form tubular structures called hyphae have cross-walls may be a state or a state
3/fungus behaving as yeast or molds
-dimorphic fungi
-grows as molds In room-temp
-grows as a yeast in elevated temp

Question 5

Fungal diseases:

Answer 5

A/mycosis (fungal infection)
—superficial (skin and outer layer)
—cutaneous(Deep in epidermis )
—subcutaneous(dermis and subcutaneous tissue)
—systemic mycosis (primary lungs and other organs
—opertinstuic mycosis
B/Fungal allergies
By funigal spores
C/mycotoxicoiss alpha toxin

Question 6

antifungal :

Answer 6

1/Polyene Antibiotic:
Bind with sterol in the fungus cell membrane
———Nystatin: first antibiotic against fungus derived from bacteria (Natamycine—Rimocydine—-Filipin)
2/Imidazole and triazole
——Group of antifungal drugs inhabited cytochrome P450 and 14 alpha demthlase which convert lanstrol to estrole in fungal cell membrane
And also blocks steroid synthesis In human
3/Allylamines
—-like (Natfitfine butenafine
4/Echioncandin
Inhibits synthesis of glucan in cell wall (caspofungin micafunginin
5/Flucytosin