intro

Question 1

development of the head and face is one of the most complex events

Answer 1

1) TFs and signaling molecules
2) 4th week of gestation
- neural crest cells combine with mesoderm
- maxillary prominence enlarge and grow towards each other and the nasal prominences
3) disturbance creates craniofacial anomalies

Question 2

interruption or mutation

Answer 2

1) congenital anomalies of the facial and airway
2) 4th week
- 64 genes are upregulated
3) 26 genes are upregulated in frontonasal prominence
4) 6th weeks
-45 genes for lateral nasal prominence
- 36 genes for the medial nasal prominence

Question 3

5 major groups for development

Answer 3

1) polarizing signals
2) GFs and receptors
3) TFs
4) cell adhesion molecules
5) ECM