intro Flashcards
define self vs non-self
self: particles that are part of or made by your body and are tolerated by the immune system.
non-self: particles not made by your body and are recognised as potentially harmful– called foreign bodies
What do non-self particles make?
Antigens
Functions of the immune system
- immunological recognition: presence of an infection detected
- innate + adaptive immunity to help eliminate infection
- immune regulation limits damage
What immunity generates immunological memory?
adaptive immunity
What are the cells involved in antigen presentation?
macrophages, dendritic cells, and B cells
What type of granulocytes acts against extracellular bacteria & fungi & is multilobed?
neutrophils
What type of granulocyte is considered as circulating mast cells?
basophils
What type of granulocytes acts against multicellular parasites (Eg.worms)/helminths & is bilobed?
eosinophils
What is the function of dendritic cells?
Present antigen & activate T helper cells & memory cells
What are plasma cells
They are mature B cells that secrete antibodies
What cells form part of both innate & adaptive immune systems?
natural killer cells
What are the primary lymphoid organs?
foetal liver
bone marrow
thymus
What are the 3 major stages of haematopoiesis?
- haematopoietic stem cells
- progenitor cells
- mature cells
When T cells develop into mature cells, they migrate from ____ to ____.
from bone marrow to thymus
What are the secondary lymphoid organs?
lymph nodes
spleen
mucosal lymphoid tissues