intracellular signaling Flashcards
What does BMP do
promotes osteoblast differentiation which accelerates bone formation/healing.
Defective; Ectopic bone formation
what are the important players in signal transduction
GF receptors; receptor kinases Signaling molecules Transcription factors this leads to--> gene regulation/cell response
What are signal transducers
they are protein signaling molecules which can transmit information in the cells
what are transcription factors
proteins that bind to the specific DNA sequences, thereby controlling the transcription of gene from DNA to messenger RNA.
they can act as an activator or repressor of gene regulation.
what is required from GF to receptor
direct binding;
protein-protein interaction
what is required from signaling molecules to transcription factors
protein modifications such as phosphorylation
Activation of TGF-beta/BMP signaling is via
Phosphorylation of the Smad complex (Ser)
what cellular events are triggered by signal transduction
Cell: Proliferation Cycle Differentiation Mov
