Intorduction To Reproduction And Endocrinology Flashcards

1
Q

•Life cycle of a cell is referred to as the ____
•CC = _____

A

Cell Cycle-CC
ordered set of events, culminating in cell growth & division into 2 daughter cells.

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2
Q

‘’ ______ is a process of cell division resulting in ______ daughter cells.
̈ All ______ divide by mitosis; the _____ divide by meiosis to produce _____.
̈ The period between mitosis is called the _____ which covers the ____ , ____ and ___ phases of CC.
̈ During ___ phase, DNA has been replicated and the chromosome number is ____
̈ In the ______, chromosomes are not visible by ______ because chromatin diffuses throughout the nucleus.
̈ Mitosis ends with _____

A

• Mitosis, 2 genetically equivalent
• Body cells; germ cells,gametes
•Interphase; G1,S and G2
• G2; 4n
• Interphase,Light microscopy
• 2 identical cells (2n)

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3
Q

_____ is a special type of cell division resulting in ______ daughter cells, each containing _____ the number of chromosomes of the parent cell.
̈ ______ (____& ____) are produced by meiosis.
̈ Meiosis —> produces cells half chromosome number = _____ (sperm & egg - _____).
̈ Fertilization (sperm + egg) —–> chromosome number = _____
̈ 2 Divisions: ______ & ______

A

• Meiosis;4 genetically nonequivalent;half
• Germ cells(eggs and sperms)
•23;haploid
• 46
• Meiosis I and Meiosis II

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4
Q

̈ The Meiosis involves ___ consecutive cell divisions.
̈ Each division is composed of ____ stages as in mitosis.
” However, the 1st division differs in some important aspects. What stages in meiosis I are different from mitosis ?

A

• two(2)
• Four(4)
• Prophase I.
Metaphase I
Anaphase I.

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5
Q

In Prophase:
• Chromosomes ____.
• SYNAPSIS - homologs ___ together = ____.
• CROSSOVER - exchange occurs at a ____
In Metaphase I = chromosomes ____.
In Anaphase I = chromosomes _____
In Telophase I = chromosome at poles - ______.
̈ Meiosis I separates _____ of homologous pair

A

• condense
• PAIR , tetrad
• chiasma
• align at equator
• migrate towards the poles
• cell domains separate
• Homologs

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6
Q

List the five substages of Prophase I

A
  1. Leptotene
  2. Zygotene
  3. Pachytene
  4. Diplotene
  5. Diakinesis
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7
Q

• After the 1st division of Meiosis the chromosome number in each daughter cell becomes ____.
̈ The process of the 2nd division is the same as in mitosis except that there is ________. As a result, the produced cell is a ____ .

A

• 2n
• no DNA replication during interphase
• haploid (1n)

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8
Q

• Meiosis II is similar to mitosis but without an ____
• Separates ______ of ____ homolog of the homologous pair just as is in mitosis.
• In human oocyte, Meiosis I is completed shortly before _____.
• Meiosis II starts without ______.
• Once secondary oocyte shows spindle,
_____ occurs.
• Meiosis II is completed at ______

A

• S phase
• chromatids,one
• ovulation
• DNA replication
• ovulation occurs
• Fertilization

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9
Q

Gametogenesis:
Spermatogenesis:
Oogenesis:

A

• Gamete formation by Meiosis
• Sperm formation (1n)
• Egg formation (1n)

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10
Q

Spermatogenesis occur has a ___-day cycle which is subdivided into ____ stages with each stage lasting for different lengths of time.

A

• 74 day cycle
• Four

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11
Q

Pertaining to spermatogenesis:
First stage:
Second stage:
Third stage:
Fourth stage:

A

Mitosis of the primary spermatogonia lasts 20 days, Up to the primary spermatocytes
First meiosis lasts ~28 days For the division of the primary
spermatocytes to form secondary spermatocytes
• Second meiosis lasts a few hours For engendering the spermatids
• Spermiogenesis 21-24 days Up to the completed sperm cells

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12
Q

• Germ cell comprise _____ and ____

• ________ is the physiological changes spermatozoa must undergo in order to have the ability to penetrate and fertilize an egg. It is the _____ step in the maturation of mammalian spermatozoa and is required to render them competent to _____ an oocyte.
• Ovum is a _____ oocyte arrested at _____ in the second meiotic division

A

• Spermatozoon and Ovum
• Capacitation; penultimate; fertilize
• secondary oocyte; metaphase II

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13
Q

Process of fertilization
The Sperm binds to ______ to induce ______.

A

• Sperm receptor ZP-3
• Acrosome reaction

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14
Q

Acrosome reaction is the release of _____

A

acrosomal enzyme

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15
Q

The second meiotic division of the secondary oocyte is rapidly completed when _____ occurs and the ______ is released, leaving a ___ female nucleus.

A

Fertilization
Second polar body
Haploid

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16
Q

Consequences of fertilization:

A
  1. Completion of Meiosis II
  2. Restores diploid number of
    chromosomes
  3. Variation of human species
  4. Sex determination
  5. Metabolic activation of oocyte
  6. Initiation of clevage
17
Q

Zona reaction:

A

Zona reaction: Cortical granules→perivitelline space →degrade ZP-3, alteration of zona pellucida →barrier for sperm penetration

̈ The second meiotic division of the secondary oocyte is rapidly completed and the second polar body is released, leaving a haploid female nucleus.

18
Q

Endocrine system maintains ______ and ______ using ____ or _____
•These hormones are _____ released into the ______ and arrive at their appropriate ______ with specific ______
•In contrast, the nervous system coordinates ______ and _____ responses to stimuli using _______ that travel along neuron axons

A

• homeostasis & long- term control; chemical signals or hormones
• chemicals, bloodstream, target cells, receptors
• rapid and precise, action potentials

19
Q

________ are specific cells affected by a hormone
Endocrine: circulated by _____ to target cells
Paracrine: Hormones that affect ______
Juxtacrine*
Autocrine: Hormones that act on the ______
Neuroendocrine pathway (hormones that are released by _____ to reach the ____)

A

• Target cells/tissues
• blood
• neighboring cells
• cells that secrete them
• neurons,target cells

20
Q

Lipid-Soluble or Steroid Endocrine Hormones:

A

Aldosterone,
Calcitriol,
Testosterone,
Estrogen,
Progesterone,
T3 & T4

21
Q

Water soluble hormones are :

A

Catecholamines
Peptides/Protein
Anterior Pituitary Hormones
Parathyroid hormones
Pancreas hormones

22
Q

Water soluble hormones- Catecholamines consist:

A

Epinephrine Norepinephrine

23
Q

Water soluble hormones- Peptides/Proteins consist:

A

All Hypothalamic releasing/inhibiting hormones
Oxytocin
ADH

24
Q

Water soluble Anterior Pituitary Hormones are:

A

Follicle Stimulating Hormone
Thyroid Stimulating Hormone
Adrenocorticotropic Hormone
Leutinizing Hormone
Melanocyte Stimulating Hormone
Prolactin
Human Growth Hormone

25
Q

Water soluble pancreas hormones:

A

Glucagon
Insulin
Somatostatin
Pancreatic polypeptide

26
Q

Calcitonin is a _____ -soluble hormone.

A

Water soluble Hormone

27
Q

Concerning hormone interactions:
Explain Down-Regulation
Up-regulation
Permissive effect

A

Down-regulation:
decrease in target cell receptors when excessive hormone is present
Up-regulation:
Increase in target cell receptors when there is a deficiency of hormone
Permissive Effect:
When the actions of a hormone on target cells requires a simultaneous or recent exposure to a second hormone

28
Q

̈ Hormones can increase activity of another hormone or increase sensitivity of target cell to a hormone, this is known as _____
̈ Uterus exposed to estrogen induces formation of ______
̈ Glucocorticoids permissive on ______
̈ PTH has a permissive effect on actions of _________ (stimulates production of hydroxylating enzymes in ____ and ____ ) and stimulates absorption of ___

A

•Permissive Effect of hormones
• progesterone
•catecholamines
• vitamin D3
•kidney and liver; calcium

29
Q

Explain the synergistic effects and antagonistic effects of hormones:

A

Synergistic Effect:
Two hormones acting together have a greater or more extensive effect.
Antagonistic Effect:
One hormone opposes the action of another hormone.

30
Q

Hypothalamus, also known as ______ controls the activity of the _____ by releasing hormones called ______ hormones

A

• Master gland
• Pituitary gland
• Releasing/inhibiting hormones

31
Q

• Hormones of the Hypothalamus are:
• All of these are released into the blood in _______ & travel immediately – in _____– to a ______ in _______ , where they exert their effects
•All of them are released in _____

A
  1. Thyrotropin-releasing hormone (TRH)
  2. Gonadotropin-releasing hormone (GnRH)
  3. Growth hormone-releasing hormone (GHRH)
  4. Corticotropin-releasing hormone (CRH)
  5. Somatostatin
  6. Dopamine

• Capillaries
Portal veins
2nd capillary bed
Anterior Pituitary

•Periodic spurts

32
Q

• Pituitary gland is divided into ____ lobes:

A

Anterior Lobe (aka adrenohypophysis)
Posterior lobe (aka neurohypophysis)

33
Q

Anterior lobe of pituitary gland is aka ______ and is referred to as ____ because it secretes ______.

A

Adrenohypophysis
True gland
Hormones

34
Q

Posterior lobe of pituitary gland is also known as _____ and is connected to the _____ through the ______ tract.
The posterior lobe stores hormones secreted by _____

A

• Neurohypophysis
• Hypothalamus
• Hypothalamo-hypophyseal Tract
• Hypothalamic nuclei