Intertriginous/axillary granular parakeratosis

Question 1

Two main populations affected by axillary granular PK?

Answer 1

• adult women>infants (diaper area)

Question 2

Intertrigenous/axillary Parakeratosis presents as:

Answer 2

• pruritic, keratotic red-brown papule and plaques in the intertrigenous areas (axillae>inguinal, inframammary)

Question 3

Etiology of axillary granular parakeratosis?

Question 4

Histoloy of Axillary granular parakeratosis:

Answer 4

• characteristic thickened eosinophilic stratum corneum w/ prominent parakeratosis and retained keratohyaline granules

Question 5

Prognosis of axillary granular PK?

Answer 5

• Can be chronic/recurrent

Question 6

Treatment of axillary granular PK?

Answer 6

• topical corticosteroids are mainstay
• also topical vitamin D analogues, keratolytics, and antifungals
• can try destruction with cryotherapy
• if severe can use systemic isotretinoin or systemic antifungals