Confluent and reticulated papillomatosis (CARP)

Question 1

CARP starts at _____ age, affects____ (M or F) more, affects _____(Blacks or whites) more.

Answer 1

• Starts at puberty
• affects F>M
• affects blacks>whites

Question 2

Etiology of CARP

Answer 2

• unknown

Question 3

Clinical presentation of CARP:

Answer 3

• Red or brown, rough, keratotic, slightly raised papules that first appear in intermammary region–> then spreads outward and forms reticulated pattern laterally
• can have features similar to Tinea versicolor and acanthosis nigricans

(more confluent centrally, and reticulated laterally)

Question 4

Histology of CARP:

Answer 4

• acanthosis nigricans-like:

- Hyperkeratosis, acanthosis, papillomatosis

Question 5

Treatment of choice for CARP:

Answer 5

• Minocycline 100mg BID x 6 weeks (effective in 50%)
• Other options: Oral retinoids, oral antibiotics, topical antifungals

Question 6

Variant of CARP that occurs on neck as vertically-oriented hyperpigmented papillomatous lesions w/ wrinkling is called______.

• Treat this with ____

Answer 6

• Pseudoatrophoderma colli
• minocycline (same as CARP)