Interstitial nephritis

Question 1

Acute interstital nephritis is assocoicated w what condition

Answer 1

Drug- induced AKI

Question 2

MOST COMMON drug causes of acute interstitial nephritis

Answer 2

Penicillin, b lactams, fluroquinolones, cephalosporins.
NSAIDs
allopurinol
furosemide
Rifampicin.
PPIs

Question 3

other conditions causing acute interstitial nephritis

Answer 3

SLE , Sarcoidosis, Sjorgen syndrome - sss.

Hanta virus, staphylococci

Question 4

featuresof interstital nephritis

Answer 4

Fever, rash, arthralgia
Eosinophilia
HTN

Question 5

Investigations of interstital nephritis

Answer 5

Medication review
sterile pyuria - no bacs in urine but high WCC leukcytes or pus in urine.
white cell casts

Question 6

Tx of interstitial nephritis

Answer 6

stop causative drug
glucocorticoid therapy if no improvements after stopping.

Question 7

differential diagnosis: of intestitial nephrtis

Answer 7

Pre renal AKI –> low urine NA + high urine osmolality + improvement w fluid resus

Intrinsic aki -> ATN muddy brown cast + acute onset. Glomerulonephritis haemturia + RED cell casts.

Post-renal aki -> symps of BOO + bilateral hydronephrosis.