Interstitial lung disease: sarcoidosis (R2)

Question 1

What is sarcoidosis?

Answer 1

Adaptive immune response throughout the body, in the absence of a pathogen

Question 2

Describe the pathophysiology of sarcoidosis

Answer 2

T cells and macrophages are attracted to healthy tissue and form non caseating granulomas.

Question 3

Where can the granulomas be found?

Answer 3

Can involve nearly every organ
However, most often involve the hilar lymph nodes of the lung

Question 4

Risk factors for sarcoidosis?

Answer 4

Demographics: African American women
PMHx: prior infection with TB and Bonelia burgdorferi
Family history: of sarcoidosis

Question 5

History?

Answer 5

Constitutional symptoms: fever, night sweats, fatigue, weight loss
Location specific symptoms
- Lungs: SOB, coughing
- Eyes: vision changes
- Skin: erythema nodosum

Question 6

Investigations

Answer 6

Question 7

Management

Answer 7

Steroids
Immunomodulatory therapies - if corticosteroid refractory