Interstitial Lung Disease (PATHOLOGY) Flashcards

1
Q

What is the early stage of interstitial lung disease?

A

Alveolitis

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2
Q

What is the late stage of interstitial lung disease characterised by?

A

Fibrosis

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3
Q

What exemplifies acute ILD?

A

Adult Respiratory Distress Syndrome (ARDS)

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4
Q

What causes the clinical features of ILD?

A

Respiratory and cardiac failure leading to hypoxia

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5
Q

What are the environmental causes of ILD and what do they lead to?

A

Mineral/drugs/radiation/post-ARDS

Lead to hypersensitivity

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6
Q

Idiopathic ILD causes …?

A

Connective tissue disease

Fibrosing Alveolitis

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7
Q

What are to two methods for taking a biopsy in ILD?

A

Transbronchial biopsy

Thoracoscopic biopsy

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8
Q

What are the main chronic ILDs?

A
Fibrosing alveoli's
Sarcoidosis
Extrinsic allergic alveoli's
Pneumoconiosis 
Connective tissue diseases
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9
Q

What characterises fibrosing alveolitis?

A

Progressive interstitial fibrosis of unknown cause

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10
Q

Patient with finger clubbing, dyspnoea and pulmonary fibrosis probably has…

A

Fibrosing alveolitis

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11
Q

What is extrinsic allergic alveolitis?

A

Chronic inflammatory disease of the small always and interstitum with occasional granulomas and a type III/IV hypersensitivity allergic origin

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12
Q

What are the causes of EAA?

A

Thermophilic bacteria - Farmer’s lung
Avian proteins - Bird fanciers lung
Fungi - Malt worker’s lung

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13
Q

How can EAA be diagnosed?

A

Detectable antibodies in serum

Biopsy for unusual cases

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14
Q

What is sarcoidosis?

A

Multisystem granulomatous disorder of unknown cause with common pulmonary involvement

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15
Q

How is sarcoidosis usually treated?

A

Most cases are mild and self-limiting

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16
Q

What are commonly affected tissues of sarcoidosis besides the lungs?

A

Uveitis
Erythema nodosum
Lymphadenopathy
Hypercalcaemia

17
Q

What is caused by connective tissue disease in the lungs?

A

Interstital fibrosis (milder than fibrosing alveolitis, doesn’t progress as rapidly)
Pleural effusions
Rheumatoid nodules

18
Q

What is pneumoconiosis?

A

Lung disease caused by mineral dust exposure

19
Q

Which conditions are examples of pneumoconiosis?

A

Asbestosis
Coal worker’s lung
Silicosis

20
Q

The disease of pneumoconiosis depends on which 4 factors?

A

Particle size
Reactivity of particle
Clearance of particle
Host response

21
Q

Asbestos causes…

A

Parietal pleural plaques
Interstitial fibrosis (asbestosis)
Bronchial carcinoma
Mesothelioma

22
Q

What are the two different types of asbestos fibres?

A

Serpentine (curved)

Straight (amphibole)

23
Q

Are serpentine or straight asbestos fibres more dangerous? Why

A

Straight

Serpentine are usually caught in upper airways and coughed out