Interstitial Lung Disease Flashcards
What are the radiological features of ILD?
reticulation traction bronchiectasis honeycombing architectural distortion volume loss
What are the radiological features of usual interstitial pneumonia?
subpleural reticulation
apical-basal gradient (worse basal)
traction bronchiectasis
honeycombing
What are the radiological features of non specific interstitial pneumonia?
ground glass change
apical to basal gradient
subpleural sparing
traction bronchiectasis
What are the radiological/histological changes on idiopathic pulmonary fibrosis?
usual interstitial pneumonia
What are the risk factors for IPF?
older age (6th-7th decade) male past smoking history GORD FHx ILD
What are the treatments for IPF?
pirfenidone
nintedanib
What is the mechanism of action of pirfenidone?
acts through TGF-B and reduces fibroblast proliferation
What are the major side effects of pirfenidone?
nausea/GIT SEs
photosensitivity rash
What is the mechanism of action of nintedanib?
inhibits multiple tyrosine kinases
What are the side effects of nintedanib?
diarrhoea
weight loss
possible CV risk
possible small increase in bleeding risk
What did the SENSCIS study show?
that nintedanib also has benefit for systemic sclerosis associated ILD
What percentage of patients with IPF have a genetic abnormality associated with telomeres?
25-30%
