Interpreting NMR Flashcards
What can NMR spectroscopy be used to study?
NMR spectroscopy can be used to study the structures of organic compounds.
What type of NMR spectroscopy was used to study Compound J?
‘H NMR spectroscopy.
Identify a solvent in which Compound J can be dissolved before obtaining its ‘H NMR spectrum.
CDCl3.
What is the number of peaks in the ‘H NMR spectrum of Compound J?
The number of peaks in the ‘H NMR spectrum of J is 3.
What is the splitting pattern of the protons labelled a in Compound J?
The splitting pattern of the protons labelled a is a triplet.
What is the IUPAC name of Compound J?
The IUPAC name of J is 2-methylpropan-2-ol.
What type of NMR spectroscopy was used to study Compound K?
13C NMR spectroscopy.
What is the number of peaks in the 13C NMR spectrum of Compound K?
The number of peaks in the 13C NMR spectrum of K is 5.
What is the suggested δ value of the peak for the carbon labelled b in Compound K?
The suggested δ value for the carbon labelled b is approximately 30-35 ppm.
What is the IUPAC name of Compound K?
The IUPAC name of K is 2-hexanol.
What type of medicine is atenolol?
Atenolol is a beta blocker.
What is the function of beta blockers like atenolol?
They are used to lower blood pressure by slowing the heart rate.
What are the names of the circled functional groups labelled J and K on the structure of atenolol?
J is an amine and K is an alcohol.
What is the range of δ values for the peak produced by the CH3 group labelled p in the ‘H NMR spectrum of atenolol?
The range of δ values for this peak is approximately 0.8-1.2 ppm.
What is the splitting pattern of the peak produced by the CH3 group labelled p in atenolol?
The splitting pattern of this peak is a triplet.
Why was CDCl3 used as the solvent for the ‘H NMR spectrum of atenolol?
CDCl3 was used because it is deuterated, which avoids interference in the spectrum.
Why is CDCl3 a more effective solvent than CCl4 for polar molecules like atenolol?
CDCl3 is more effective because it can dissolve polar molecules better due to its polarity.
What was recorded in 2013 related to atenolol?
The 13C NMR spectrum of atenolol was recorded.
What should be deduced from the structure of atenolol?
The total number of peaks in the 13C NMR spectrum of atenolol.
What is the formula of the compound used as a standard in the NMR spectrum?
The compound that produces the peak at δ = 0 ppm.
What is the δ value of the peak produced by the CH3 group in atenolol?
Identify this peak in the spectrum by stating its δ value.
How many CH3 groups are in the structure of atenolol?
There are three CH3 groups in the structure of atenolol.
What peak does one of the CH3 groups produce in the 13C NMR spectrum?
The peak at δ = 71 in the 13C NMR spectrum.
What is the industrial production method of atenolol?
Atenolol is produced industrially as a racemate by reduction of a ketone.
What is the effect of the enantiomers of atenolol?
Both enantiomers are able to lower blood pressure.
What has recent research shown about the enantiomers of atenolol?
One enantiomer is preferred over the other.
What is a suggested reducing agent for forming atenolol?
Suggest a reducing agent that can reduce a ketone to form atenolol.
What should be circled in the structure of atenolol?
Circle the carbon atom in the structure of atenolol.
How can the production of atenolol as a racemate be shown?
Suggest how to show that its production process by reduction of a ketone was a racemate.
What is one advantage of using a racemate in medicines?
Suggest one advantage of using a racemate rather than a single enantiomer in medicines.
What is one disadvantage of using a racemate in medicines?
Suggest one disadvantage of using a racemate rather than a single enantiomer in medicines.
