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first aid immune > Interleukins > Flashcards

Interleukins Flashcards

1
Q

IL-2`

A

PROLIFERATION of T CELLS

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2
Q

IL-4

A

proliferation of B cells, Th 0 –> Th2

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3
Q

IL-5

A

proliferation of B cells

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4
Q

IL-10

A

Inhibits Th1 and macrophages

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5
Q

IL-12

A

th0 –> th1 cells

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6
Q

IFN GAMMA

A

activates Macrophages

inhibits Th2 cells

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7
Q

what do Th1 cells mainly produce

A

IL-2

IFN gamma

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8
Q

what do Th2 cells mainly produce

A

IL-4

IL-5

IL-10

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9
Q

What produces IL-12

A

macrophages.

and also dendritic cells?

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10
Q

IL-10 inhibits

A

Th 1 cells

also IL-4 inhibits them too.

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11
Q

IFN-gamma inhibits

A

Th2 cells

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12
Q

what cytokines are produce by

Th 1 cells

A

IL-2

IL3

IFN-gamma

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13
Q

what cytokines are produce by

Th2 cells

A

IL-3

IL-4

IL-5

IL-10

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14
Q

what cytokines

promote growth and differentiation of

B cells

A

IL-4

IL-5

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15
Q

What cytokine promotes

growth and activation of EOSINOPHILS

A

IL-5

Remember is associated with mucus

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16
Q

what cytokines are

pyrogens

secreted by macrophages

A

IL-1

IL-6

17
Q

What cells secrete IL-12 that functions to?

A

macrophages secrete IL-12

functions to stimulate Th0 cells to differentiate into Th1 , and activates NK cells

18
Q

IL-12 def can result in

A

mycobacterial infections

because no IL-12 to stimulate differentiation into Th1 cells thus no secretion of IFN gamma from TH1 to activate macrophages

19
Q

what cytokine enhances synthesis

of IgE and IgG

” BEG 4 it”

A

IL-4

20
Q

what cytokine enhances synthesis of

IgA

A

IL-5

21
Q

What cytokines mediate inflammation

(acute phase cytokines)

A

IL-1

IL-6

TNF-a produced by macrophages

22
Q

secreted by

Th-1 cells and activates macrophages****

A

IFN-gamma

23
Q

secreted by Th-2 cells

and inhibits macrophage activation

(or inhibits activated macrophages)

A

IL-10

24
Q

inhibits production of

Th1 cells

A

IL-10

25
Q

INHIBITS production of

Th-2 cells

A

IFN-gamma

26
Q

cytokine released by virus infected cells

A

IFN-a

IFN - B

27
Q

what cytokine

supports growth and differentiation of bone marrow stem cells

A

IL-3

28
Q

Supprots T cell

proliferation, differentiation, and activation

A

IL-2

Secreted by TH-1 cells

29
Q

High dose of IL-2

can treat what and whats the mech

A

high dose of il-2 –> reduction in tumor cells

by?

*** enhancing activity of NK cells

30
Q

what is the function of macrophages in the spleen

A

remove encapsulated bacteria

remove dysfunction red cells

first aid immune (6 decks)

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