Interleukins Flashcards
IL-2`
PROLIFERATION of T CELLS
IL-4
proliferation of B cells, Th 0 –> Th2
IL-5
proliferation of B cells
IL-10
Inhibits Th1 and macrophages
IL-12
th0 –> th1 cells
IFN GAMMA
activates Macrophages
inhibits Th2 cells
what do Th1 cells mainly produce
IL-2
IFN gamma
what do Th2 cells mainly produce
IL-4
IL-5
IL-10
What produces IL-12
macrophages.
and also dendritic cells?
IL-10 inhibits
Th 1 cells
also IL-4 inhibits them too.
IFN-gamma inhibits
Th2 cells
what cytokines are produce by
Th 1 cells
IL-2
IL3
IFN-gamma
what cytokines are produce by
Th2 cells
IL-3
IL-4
IL-5
IL-10
what cytokines
promote growth and differentiation of
B cells
IL-4
IL-5
What cytokine promotes
growth and activation of EOSINOPHILS
IL-5
Remember is associated with mucus
what cytokines are
pyrogens
secreted by macrophages
IL-1
IL-6
What cells secrete IL-12 that functions to?
macrophages secrete IL-12
functions to stimulate Th0 cells to differentiate into Th1 , and activates NK cells
IL-12 def can result in
mycobacterial infections
because no IL-12 to stimulate differentiation into Th1 cells thus no secretion of IFN gamma from TH1 to activate macrophages
what cytokine enhances synthesis
of IgE and IgG
” BEG 4 it”
IL-4
what cytokine enhances synthesis of
IgA
IL-5
What cytokines mediate inflammation
(acute phase cytokines)
IL-1
IL-6
TNF-a produced by macrophages
secreted by
Th-1 cells and activates macrophages****
IFN-gamma
secreted by Th-2 cells
and inhibits macrophage activation
(or inhibits activated macrophages)
IL-10
inhibits production of
Th1 cells
IL-10
