Intercalating Agents

Question 1

DNA Intercalating Agents

Answer 1

Intercalates between base pairs (GC). Block DNA and/or RNA synthesis. Causes strand breakage SS or DS. Cell Cycle Non Specific.

Question 2

Dactinomycin

Answer 2

Intercalates between GC pairs. Block RNA synth. causes SS break.

Use: Pediatric tumors ( Wilm’s, Ewing)

Question 3

Daunorubicin

Answer 3

Class: Anthracycline

Intercalates. Forms H2O2 which in the presence of Fe forms OH radicals which then cleaves DNA

Use: AML

Side Effects: Cardiac toxicity + alopecia

Miscl: Dextrazoxane is cardio protective.

Question 4

Doxorubicin

Answer 4

Class: Anthracycline

Intercalates. Forms H2O2 which in the presence of Fe forms OH radicals which cleave DNA

Use: breast, lung, sarcomas, lymphomas

Side Effects: Cardiac toxicity + alopecia

Miscl: Dextrazoxane is cardio protective.

Question 5

Epirubicin

Answer 5

Class: Anthracycline

Intercalates. Forms H2O2 which in the presence of Fe forms OH radicals which cleave DNA

Use: Breast and gastric
Side Effects: Cardiac toxicity + alopecia

Miscl: Dextrazoxane is cardio protective.

Question 6

Bleomycin

Answer 6

Class—

Bind ands causes SS + DS breaks in DNA.

Use: Testicular, squamous cell carinoma, lymphoma

Side Effects: Lung Toxicity, Cutaneous Toxicity, Hyperthermia