Interactions Flashcards
Antibiotics which interact with warfarin
Erythromycin, raises INR.
Drugs which inhibit P450 liver enzyme activity and therefore decrease drug concentrations
Phenytoin Carbamazepine Rifampicin Sulfonylurea (gliclazide) Chronic excessive alcohol consumption
Drugs which activate P450 liver enzymes and therefore increase drug concentrations
Sodium valproate Allopurinol Omeprazole Erythromycin Ciprofloxacin Isoniazid Sulphonamides Disulfiram (alcohol withdrawal) Ethanol (acute intoxication)
What drugs must be used with caution in someone with a penicillin allergy
- Co-amoxiclav and Tazocin obviously
- Cephalosporins e.g. Ceftriaxone, Cefotaxime
- Other beta-lactam ring compounds e.g. carbapenems (meropenem)
Contraindications to use of NSAIDs
Renal failure
Severe heart failure
Hx of GI bleed due to NSAIDs / Active GI bleed
Use with caution in asthma and coagulation/clotting defects.
Anti-emetic CI in parkinsons and can cause bradykinesia and rigidity
metoclopramide as dopamine antagonist
Warfarin and tamoxifen
Tamoxifen increases effect of warfarin, higher INR readings
2 drugs which should never be used in pts on methotrexate and why
Trimethopim and co-trimoxazole as they are folate antagonists. Increase MTX effects could be potentially toxic
Carbamazepine electrolyte imbalance caused
Hyponatraemia, consider use of lamotrigine.
Renal or liver impairments accumulates digoxin
Renal
Main class of DM drugs which cause hypoglycaemia
Sulfonylureas e.g. gliclazide
Which 3 of these drugs can cause hyperlipidaemia: Acarbose Amitriptyline Amlodipine Bendroflumethiazide Gliclazide Lamivudine Olanzapine Pregabalin
Bendroflumethiazide
Lamivudine
Olanzapine
Electrolyte imbalance in ACEi
Hyperkalaemia and mild hyponatraemia
Drugs at risk of hypomagnesaemia
Loop diuretics Thiazide diuretics PPI Ciclosporin IV bisphosphonates IV aminoglycosides
Drugs which increase cholesterol
Systemic steriods Antipsychotics Cyclosporin HIV meds SGLT2 (-flozins) Some diuretics
