Interactions Flashcards
1
Q
Inducers of the P450 system include - INR will decrease
A
antiepileptics: phenytoin, carbamazepine
barbiturates: phenobarbitone
rifampicin
St John’s Wort
chronic alcohol intake
griseofulvin
smoking (affects CYP1A2, reason why smokers require more aminophylline)
2
Q
Inhibitors of the P450 system include - INR will increase
A
antibiotics: ciprofloxacin, erythromycin isoniazid cimetidine,omeprazole amiodarone allopurinol imidazoles: ketoconazole, fluconazole SSRIs: fluoxetine, sertraline ritonavir sodium valproate acute alcohol intake quinupristin
3
Q
Beta-blockers plus WHAT never prescribed together….
A
ACEI
