Contraindications Flashcards
1
Q
Heart failure
A
thiazolidinediones*: pioglitazone is contraindicated as it causes fluid retention
verapamil: negative inotropic effect
NSAIDs**/glucocorticoids: should be used with caution as they cause fluid retention (apart from aspirin low dose)
class I antiarrhythmics; flecainide (negative inotropic and proarrhythmic effect)
2
Q
Pregnancy
A
Antibiotics tetracyclines aminoglycosides sulphonamides and trimethoprim quinolones: the BNF advises to avoid due to arthropathy in some animal studies
Other drugs ACE inhibitors, angiotensin II receptor antagonists statins warfarin sulfonylureas retinoids (including topical) cytotoxic agents
