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BNF > Interactions > Flashcards

Interactions Flashcards

1
Q

Enzyme Inducers

A

GP RAPS
Griseofulvin
Phenytoin
Rifampicin
Alcohol (chronic use)
Phenobarbital
Sulfonylureas

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2
Q

Enzyme inhibitors

A

SIC FAM

Sodium valproate
Isoniazid
Cimetidine
azole anti-Fungals
Alcohol (acute/binge)
Macrolides and Metronidazole

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3
Q

Griseofulvin interaction mechanism

A

Hepatic CYP450 3A4 enzyme inducer.
Will reduce exposure of concomitantly used drugs that are metabolised by this enzyme.

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4
Q

Phenytoin interaction mechanism

A

Hepatic CYP450 (many subtypes including 3A4 and 2D6) enzyme inducer.
Will reduce exposure of concomitantly used drugs that are metabolised by these enzymes.

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5
Q

Rifampicin interaction mechanism

A

Hepatic CYP450 enzyme inducer, including CYP3A4.
Will reduce exposure of concomitantly used drugs that are metabolised by these enzymes.

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6
Q

Alcohol (chronic use) interaction mechanism

A

Hepatic CYP450 enzyme inducer, including CYP2E1.
Will reduce exposure of concomitantly used drugs that are metabolised by these enzymes.

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7
Q

Phenobarbital interaction mechanism

A

Increases expression of various CYP450 enzymes including CYP3A4 and CYP2B6.

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8
Q

Sodium valproate interaction mechanism

A

Inhibits various CYP450 enzymes, including CYP2C9.
Will increase exposure of concomitantly used drugs that are metabolised by these enzymes.

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9
Q

Isoniazide interaction mechanism

A

Inhibits various CYP450 isoforms including CYP3A4 and CYP2C19.
Will increase exposure of concomitantly used drugs that are metabolised by these enzymes.

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10
Q

Cimetidine interaction mechanism

A

Reversibly inhibits CYP450 isoforms such as CYP2C11 and CYP2D6.
Will increase exposure of concomitantly used drugs that are metabolised by these enzymes.

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11
Q

Azole antifungals interaction mechanism

A

Inhibits CYP3A4 and other CYP450 isoforms
Will increase exposure of concomitantly used drugs that are metabolised by these enzymes.

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12
Q

Alcohol (acute/binge) interaction mechanism

A

Inhibits CYP2C9.
Will increase exposure of concomitantly used drugs that are metabolised by these enzymes.

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13
Q

Macrolide antibiotics interaction mechanism

A

Inhibits CYP3A4 and other CYP450 isoforms
Will increase exposure of concomitantly used drugs that are metabolised by these enzymes.

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14
Q

Metronidazole interaction mechanism

A

Inhibits CYP3A4/5 and other CYP450 isoforms
Will increase exposure of concomitantly used drugs that are metabolised by these enzymes.

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15
Q

CYP3A4 substrates

A

Paracetamol
Codeine
Losartan
Diltiazem

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BNF (4 decks)

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