Integument Flashcards
Characteristics of the Epidermis
- Tough, leathery outer surface of skin
- .05-.15 mm in thickness (up to 1.4 in thick skin)
- 5 layers
- Fairly avascular
how often does the epidermis regenerate?
every 14-21 days
Cell components of the epidermis
Keratinocytes, Eosinophils, Melanocytes, Lymphocytes, Langerhans cells, Merkel and Basal Cells
Layers of the epidermis
- Stratum Basale
- Stratum Spinosum
- Stratum Granulosum
- Stratum Lucidum
- Stratum Corneum
Stratum Basale
- Single row of keratinocytes (produce keratin)
- Deepest layer
- Attached to dermis via basement membrane (extra-cellular) and basal cells
- Diffusion through the basement membrane is how the epidermis receives its nutrition
- Concentration of Merkel cells
Stratum Spinosum
- Several rows of mature, slightly flattened keratinocytes called tonofibrils
- Melanocytes appear between stratum basale and stratum spinosum
- Appear “spiny” due to kearatin filaments
- Where most Langerhans cells are found
Stratum Granulosum
- 3-5 rows of flattened cells
- increased keratin concentration
Stratum Lucidum
- Few layers of flattened cells, densely packed
- Mostly flattened eosinophils
- Dead keratinocytes
Stratum Corneum
- Outermost layer
- 15-20 cells thick (dead keratinized cells)
- 3/4 of the thickness of epidermis
Melanocytes
produce the pigment melanin
Merkle Cells
specialized mechanoreceptors for light touch
Langerhan’s Cells
- found in deeper layers
- help to fight infection
What do keratinocyte (living and dead) provide?
mechanical strength
Non-cellular components of the epidermis
a. Basement membrane – binds dermis to epidermis
b. Desmosomes – between epithelial cells; bond them together
c. Hemidesmosomes – bind basal cells to basement membrane
d. Tonofibrils – protects skin from friction and pressure
e. Hair follicles
f. Sudoriferous Glands
What are Sudoriferous Glands
- Present everywhere except the lips and ears
- Secrete sweat in to ducts
- Helps to decrease the growth of bacteria
Characteristics of the Dermis
2-4 mm thick
layers are less defined than in epidermis
Papillary Dermis
- Superficial layer
- Contain FIBROBLASTS, mast cells and macrophages
- Loosely woven fibers with ground substance
- Ridges and valleys conform to the contours of the
__________________ layer of the epidermis and
creates an anchor - Where blisters occur
Reticular Dermis
- Dense, irregular CT
- Primarily type I collagen
- Has elastin fibers
- Location of nerve endings, glands and hair follicle plexus
- Deepest layer
- Gives structural support