Integ Flashcards
Macule
Circumscribed, flat discoloration that is blue, red, brown, or hypopigmented. <0.5 cm in diameter. If lesion >0.5 cm, it is a patch
freckles, petechiae, measles, flat mole (nevus), café-au-lait spots, vitiligo (complete depigmentation)
Papule
Elevated, solid lesion. <0.5 cm in diameter. Color varies. If lesion is >0.5 cm in diameter, it is a nodule
Examples: wart (verruca), elevated moles, lipoma, basal cell cancer
Vesicle
Circumscribed, superficial collection of serous fluid. <0.5 cm in diameter. If lesion >0.5 cm, it is a bulla
Examples: varicella (chickenpox), herpes zoster (shingles), second-degree burn
Plaque
Circumscribed, elevated, superficial, solid lesion. >0.5 cm in diameter
Examples: psoriasis, seborrheic and actinic keratoses
Wheal
Firm, edematous, irregularly shaped area. Size varies. May last only a few hours
Examples: insect bite, urticaria, angioedema
Pustule
Elevated, superficial lesion filled with purulent fluid
Examples: acne, impetigo
What SPF should u use?
At least 15
Risk Factors For Precancerous Lesions
Fair skin
Family history
Chronic sun exposure- working out doors (construction and farmers)
Exposure to chemicals-where you live
Geographic area-living near the equator
Behavioral Factors
Blonde or red hair, blue eyes
Premalignant Skin Lesions
Actinic Keratosis &
Dysplastic Nevus Syndrome
Actinic Keratosis
Most common precancerous lesion
affect most of the older White population
Neoplasm of epidermis
Common cause is sun exposure or artificial UV light
Varied appearance
Common occurrence
Pre malignant form of…etc.
Treatment
nitrogen
chemical burns can be caused by
Results from tissue injury and destruction from acids, alkalines, and organic compounds-exp-cleaners with HCl acid
Phenols
Found in chemical disinfectants and petroleum products (creosote and gasoline) cause not only external burns but also systemic toxicity
Used for ingrown toenails to kill the growth of the toenail
Alkaline burns
Cause liquefaction necrosis, which can be more damaging
Can be more difficult to manage than acid burns because it adheres to the tissue causing protein hydrolysis and necrosis
Damage continues even after neutralization of compound
Dysplastic Nevus Syndrome or Atypical
Abnormal mole/nevis pattern
Usually greater than 5mm with irregular border and possibly notched
Varying colors of tan, brown, black, red, or pink within single mole
Most common on the back
Uncommon but can occur on scalp or buttock
Increased risk for malignant melanoma
Doubles with presence of one nevus
12 fold increase with presence of 10 or more
Shave biopsy
Single-edged razor blade used to shave off superficial lesions or small samples of a large lesion. Provides thin specimens for diagnostic purposes.
Incisional biopsy
Wedge-shaped incision made in lesion too large for excisional biopsy. Useful when the specimen needed is larger than shave or punch biopsy
Punch biopsy-special biopsy sizes 2, 4. 6
Special punch biopsy instrument of appropriate size used. Instrument rotated to appropriate level to include dermis and some fat. Suturing depends on size and site. Provides full-thickness skin for diagnostic purposes
Excisional biopsy
Used when good cosmetic results and/or entire lesion removal desired. Skin closed with subcutaneous and skin sutures
Surgery
Electrocoagulation & electrodesiccation
Electrodessication
usually involves more superficial destruction. It uses a monopolar electrode
Electrocoagulation
Major uses of these therapies are coagulation of bleeding vessels to obtain hemostasis and destruction of small telangiectasias (dilation of groups of superficial capillaries and venules).
Curettage
the removal and scraping away of tissue using an instrument called a curette (scooping)
Cryosurgery
is the use of subfreezing temperatures to destroy epidermal lesions
Useful for precancerous lesion, skin tags, warts
Forms a blister and scab will fall off in 1-3 weeks-minimal scarring occurs
Topical liquid Nitrogen (dry ice)
Surgical excision
Should be considered if lesion involves the dermis
Complete closure of the excised area typically results in a good cosmetic result
Mohs surgery
Specific type of excision is most surgery and is microscopically controlled-removal of cutaneous malignancies
Is removed in thin horizontal layers-so 100% of margin can be examined
Any residual tumor not removed by the first excision is removed in serial excisions done the same day
Can go very deep
Consent is needed, may need cauterized after, and need proper wound/dressing care
Chemical peel
improves the aged and photodamaged skin along with acne, scarring, freckles, actinic and seborrheic keratosis
May have some loss of melanin and swelling
Should avoid sunscreen or sun immediately after a peel
5 –FU
Fluorouracil is a topical cytotoxic agent with selective toxicity for sun-damaged cells
Available in 4 different strengths
Used to treat precancerous lesions (especially AK) and some skin cancers
Patient compliance is essential with use
Teach patient-they will get re, itchy, irritated, and have some pain but it is normal
they will look worse before they lo
Malignant Skin Cancers
Non – melanoma skin cancers
Basal Cell Carcinoma
Squamous Cell Carcinoma
Malignant Melanoma
Basal Cell Carcinoma
Most common – non – melanoma skin cancer
Often in older adults
Least deadly, slow growing
Basal Cell Carcinoma Commom Appearance
Most common – non – melanoma skin cancer
Often in older adults
Least deadly
Squamous Cell Carcinoma
A cancer arising from keratinizing epidermal cells– SCC can be aggressive and has the potential to metastasize
May lead to death if not treated early and correctly
Grows more rapidly than BCC
BCC
A cancer arising from keratinizing epidermal cells– SCC can be aggressive and has the potential to metastasize
May lead to death if not treated early and correctly
Treatment for Squamous Cell Carcinoma
Surgery is needed
Intralesional chemotherapy
Mohs micrographic surgery
Frequent follow ups are needed
Risk factors for SCC
Sun/UV exposure-tanning beds
Skin sensitivity-fair skin
10 times more likely in caucasian vs. AA people
People with red or blond hair, blue or light-colored eyes, and light-colored skin that freckles easily
Genetic-prior diagnosis, first degree relative with melanoma
Hormonal / immunologic factors-immunosuppressed
Exposure to herbicides/environmental factors
3 Types of malignant melanoma
Superficial
Lentigo
Acral
Superficial
spreading melanoma
Often occurs on sun exposed areas-legs, upper back
Frequently arises from preexisting mole
Lentigo
Commonly found on face
Often in elderly patients
Flat brown irregular patches that increase in size for many years before they even form into cancer
meligna melanoma
Acral
lentiginous melanoma
Soles, palms, mucous membranes