Insulin And Hypoglycaemics

Question 1

Which type of insulin has an intermediate action?

Answer 1

Isophane insulin

Question 2

Which types of insulin have a long duration (16-35 hours) and slower onset of action (1-2 hours)?

Answer 2

Protamine zinc insulin

Insulin zinc suspension

Insulin detemir

Insulin glargine

Question 3

Which types of insulin have a short duration (8 hours) and rapid onset of action (30-60 minutes)?

Answer 3

Soluble insulin

Rapid-acting human insulin analogues:

Insulin aspart

Insulin glulisine

Insulin lispro

Question 4

How do secretalogues work?

Answer 4

They are small molecule antagonists of the KATP channel, which enhances glucose-stimulated insulin secretion from beta cells

Question 5

What are the two types of secretalogues?

Answer 5

Sulphonylureas

Meglitinides

Question 6

Name three examples of sulphonylureas

Answer 6

Gliclazide

Tolbutamide

Chlorpropamide

Gilbenclamide

Question 7

Name two meglitinides

Answer 7

Repaglinide

Nateglinide