Insomnia Flashcards

1
Q

Transient Classification

A
  • self-limiting
  • lasts <1 week
  • may be caused by travel, hospitalization, anticipation of an important or stressful event
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2
Q

Short Term Classification

A
  • Lasts 1-3 weeks

* May result from transient that involves severe stresses (death, divorce, loss of job)

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3
Q

Chronic or long-term classification

A
  • lasts more than 3 weeks to years

* often caused by medical problems, mental disorders, substance abuse

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4
Q

Treatment Goals

A
  • normal sleep
  • awake feeling rested
  • no difficulty with daytime fatigue or drowsiness
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5
Q

Treatment of transient or short term insomnia

A
  • good sleep hygiene
  • Diphenhydramine, if needed
  • Doxylamine also available OTC but no data to support efficacy, not recommended
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6
Q

Diphenhydramine dosing

A
  • take 2 or 3 nights, skip a night and evaluate, then continue pattern if necessary
  • 25-50mg per dose taken 1-2hrs before bed
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7
Q

When can tolerance to diphenhydramine develop?

A
  • if taken nightly

* max use for insomnia is 14 days

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8
Q

When should you refer for insomia?

A
  • Chronic insomnia

* Diphenydramine is ineffective after 14 days

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9
Q

Drug-drug interactions

A
  • CNS depressants

* anticholinergics

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10
Q

Contradictions/precautions/warnings

A
  • prostatic hyperplasia/difficulty urinating
  • narrow/closed angle glaucoma
  • CV disease
  • Dementia
  • > 80 (more SE)
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11
Q

Possible Side Effects to be cautious about

A
  • next day hangover is possible
  • cognitive impairment possible
  • delirium possible
  • anticholinergic SE
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12
Q

If using a combo product (diphenhydramine/apap or asa), what should they be warned about?

A

Do not take any additional apap or asa

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13
Q

What does the PM mean?

A

it has a sedating antihistamine - diphenhydramine

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14
Q

Melatonin should be recommended when?

A
  • individuals who cannot take diphenhydramine or it does not work
  • Jet lag (A rating) (ideal for traveling 3-5 time zones)
  • insomnia, insomnia in the elderly, delayed sleep phase syndrome, sleep enhancement in healthy people (B rating)
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15
Q

When shouldn’t melatonin be recommended?

A
  • in children less than 12

* pregnant or breastfeeding

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16
Q

Melatonin MOA

A
  • hormone secreted from the pineal gland in a 24hr circadian rhythm, regulating the normal sleep/wake cycle
  • phase-shifting and sleep promoting functions
17
Q

Melatonin dosages

A
  • 0.3-5mg hs before 7 PM

* for jet lag - start on day of travel; take close to target bedtime; then nightly for several days

18
Q

L-tryptophan

A
  • not recommended

* withdrawn from market in 1990

19
Q

5-hydroxytryptophan

A
  • immediate precursor for serotonin
  • Stimulates the production of melatonin
  • not recommended due to lack of data
20
Q

Other CAM to treat insomia

A
  • Ok to use if they think it works unless it interacts with other meds
  • chamomile
  • ginseng
  • lavender
  • hops
  • lemon blam
  • passionflower
21
Q

Kava

A
  • anxiety and insomnia
  • hepatotoxic risk
  • not recommended
22
Q

Ethanol

A
  • large amounts = poorer quality of sleep

* increased awakenings during night

23
Q

Valerian

A
  • insomnia (B)
  • anxiety (C)
  • sedation( D)
  • not for acute use, takes several days or weeks
24
Q

Valerian MOA

A

*increases GABA, activity at the benzodiazepine receptor

25
Q

Valerian dosage

A
  • 400-900 mg 30-60 min before bed

* 4 weeks on, 2 weeks off

26
Q

Valerian risks

A
  • chronic use with abrupt stop can cause benzodiazepine withdrawl
  • hepatotoxic risk