Innate to adaptive Flashcards

1
Q

How many alleles code for MHC molecules?

A

Polymorphic - 9 alleles on chromosome 6

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2
Q

Alleles that code for MHC are on which chromosome?

A

Chromosome 6

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3
Q

What kind of inheritence for MHC molecules

A

Codominant

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4
Q

Which cells express MHCI molecules?

A

All nucleated cells (NOT RBC)

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5
Q

Which cells express MHCII molecules?

A

ONLY PROFESSIONAL APCs
- DC essential for primary T cell response
- macrophages & B cells augments pre-existing immune response

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6
Q

How are MHCI-peptide complexes synthesised?

A
  1. Viral proteins are ubiquinated and broken down by proteasomes into peptides.
  2. Peptide are transported to ER via TAP proteins
  3. MHC I folds with peptides and is transported to GA
  4. Fuse with plasma membrane
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7
Q

How are MHCII-peptide complexes synthesised?

A
  1. 2 chains of MHCII molecules are synthesised in the ER and binds to an invariant chain, preventing binding of intracellular pathogens.
  2. This complex is transported to the GA and then into endosomes containing extracellular pathogens.
  3. In the endosomes, invariant chain on MHC II molecules is processed into CLIP peptide, which is then replaced by antigenic peptides.
  4. Final MHC II-peptide complexes are then presented on cell surface to CD4 T cells.
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