Innate Immunity

Question 1

Paradoxically, Losing the complement inhibitory molecules “_____” or “_____”, you become more prone to infection because of C3 depletion

Answer 1

Factor H, Factor I

Question 2

For an inflammatory response, the transcription factor ______ is particuarly important

Answer 2

NF-Kappa-Beta

Question 3

In regards to complement, Factor I and Factor H both ______ _____

Answer 3

Inhibit Complement

Question 4

The Alternative pathway has Spontaneous creation of _____

Answer 4

C3a

Question 5

Type ____ and _____ IFNs are crucial to early antiviral defense

Answer 5

I, III

Question 6

Plasmacytoid Dendritic cells are special because with TLR3,7,9 they can produce _____

Answer 6

Type I Interferons

Question 7

What mechanism do neutrophils present antigen by?

Answer 7

They don’t!

Question 8

In the alternative pathway _____ is a C3 convertase that cleaves C3 into C3b and C3a

Answer 8

C3bBb

Question 9

The classical complement pathway begins through _____ _____ ____ ____

Answer 9

Antibody binding to Pathogen

Question 10

Antiviral responses work through transcription factors of the _____ Response Factor Family

Answer 10

Interferon

Question 11

The “____’s” of the complement tend to stick to cells

Answer 11

b

Question 12

In the MBL and Classical complement pathway ______ is a C3 convertase that cleaves C3 into C3b and C3a

Answer 12

C4b2a