Innate Immunity Flashcards
(32 cards)
Kill bacteria:
Pahocytosis/ degranulation/ NET
Kill parasites:
Degranulation/ cytokines
Promote inflammation:
Degranulation (Histamine/ Heparin)
Natural killer cell:
Kills infected/ cancer cells
T helper cells:
Provide help to B cells
T C Cytotoxic T cells:
Kill infected cells via MCHI
B cell:
Antibody production
Type of cells:
Innate, adaptive, interface
Innate response contains
Nk cells, macrophages, neutrophils, immature DC’s
Adaptive immune response contains:
B cells, CD4, CD8, mature DC
Innate mechanisms
Skin, mucosal surfaces, temperature, low pH, Chemical mediators
Skin:
Acidic environment inhibits growth of microbes, barrier
Mucosal surfaces:
Epithelial barrier, mucus traps foreign substances, cilia propel foreign substances out of the body
Temperature
Normal body temperature and fever responses inhibit growth of some pathogens
Low Ph
Acidity of stomach kills most invading microorganisms
Chemical mediators
Lysosyme, interferon, complement
Cytokines Chemokines
enable migration of cells from blood vessels into the tissues, produced by many cells from blood vessels into tissue
Antimicrobial peptides
Produced by phagocytes, lymphocytes, epithelial cells of GI and GU tracts, cells of the tracheobronchial tree
Complement proteins
Primarily produced in liver, factor D in adipose tissue
Interferons
Add resistance to viral replication
Endocytose
Various cells internalise and break down foreign macromolecules
Phagocytotic
Specialised cells that internalise, kill and digest whole microorganism
Macrophages stationed at:
Strategic points where microbial invasion or accumulation of airborne particles are likely to be
Alveolar macrophages
pulmonary alveolus of lungs
