Innate Immune System

Question 1

4 phases of tissue injury

Answer 1

Collagen exposure, PAF release (recruits plts+leukos), tissue factor release (starts clotting) vasoconstriction (plts+endothelial TXA2)

Question 2

Function of plts when they bind collegen

Answer 2

Release growth factors, fibrin crosslinks plts, vasodilatation ( histamine release)

Question 3

Cells that have dominant role in inflammation

Answer 3

Macrophages

Question 4

What cytokines do macros release

Answer 4

IL-1 and TNF

Question 5

Order of cell arrival in wound

Answer 5

Plts, pmn, macros, fibroblast, lymphos

Question 6

Predominant cell type by day

Answer 6

Day 0-2 =PMN, day 3-4=macros, day 5-on=fibroblasts

Question 7

Steps in wound healing

Answer 7

Inflammation (PDGF, PAF), Proliferation (PDGF, FGF, EGF), Remodeling

Question 8

What is key growth factor in wound healing.

Answer 8

Platelet derived growth factor

Question 9

Function of PDGF

Answer 9

Activates inflammatory cells, fibroblasts, angiogenesis, epitthelialization, chemotaxis, accelerates wound healing

Question 10

Platelet activating factor function

Answer 10

Activates plts, chemotaxis, adhesion molecules, and is a phospholipid

Question 11

What part of wound healing is FGF involved in

Answer 11

Proliferation, +fibroblasts, angiogenesis, epithelialization

Question 12

What phase of wound healing does epidermal growth factor

Answer 12

Proliferation

Question 13

Function of transforming growth factor beta (TGF-beta)

Answer 13

Immunosuppressive by inhibiting lymphocytes and leukocytes

Question 14

Chemo tactic factors

Answer 14

PDGF, PAF, IL-8, LTB4, c5-a, c3-a

Question 15

Angiogenesis factors produced by

Answer 15

Macrophages and platelets

Question 16

Main producer of growth factors

Answer 16

Macrophages