Innate Flashcards
Complement pathways have 3 parts:
1- Lectin Pathway
2- Classical Pathway
3- Alternative Pathway
Collection of circulating an ( membrane-associated proteins )that are important in defense against microbes is ……..
COMPLEMENT SYSTEM
coats microbes
C3 (C3b)
What is the function of C3b ?
Bind microbes to phagocytes C3b receptors for C3b that are expressed on the phagocytes
………killed; process k/a
…………….
1- Raibdly
2- opsonization
They are always triggers ( after ) (antibodies )bind to microbes or other antigens.
Classical pathway
It is triggered (start) when (complement proteins) (C2,C3,C5,…) are activated on microbial surfaces.
Alternative Pathway
It is activated by (mannose-binding lectin (MBL) ) binds to terminal mannose that present on the surface of glycoproteins on the surface of microbes
Lectin Pathway
The complement system has………… c from …………..all of c system has own role
⭐ The most important two complements are………..
1- 9
2- (c1-c9)
3-
C3 is broken off to give ……….
C3a and C3b
All complement (a) go for………….. - All complement (b) go for………..
1- inflammation
2- opsonization and phagocytosis
not all microbes can killed in early steps so it go to …………. Stage
late
On late step C5 is broken down into : …………..
. C5a: causes………….
and c6,c7,c8,c9 all of them together they make a……… ( كلام واجد )
1- C5a and C5b
2- inflammation
3-C5b and c6,c7,c8,c9 all of them together they make a hole (pore) inside the microorganism inside the microorganism Which lead to lysis of microbe then there is osmotic change and all the fluids inside the microbe goes out this called membrane attack complex (MAC)
there is osmotic change and all the fluids inside the microbe goes out this called…………
membrane attack complex (MAC)
Are examples of cytokines……..
interluekins, interferon