Injury and Healing Flashcards
What are the trauma mechanism of action?
- Low energy
- High energy
What are the stress mechanism of action?
-Abnormal stresses on normal bone
What are the pathological mechanism of action?
-Normal stresses on abnormal bone
What are the different types of soft tissue integrity fracture patterns?
open
closed
What are the different types of bone fragments fracture patterns?
greenstick
simple
comminuted
What are the different types of displacement fracture patterns?
displaced
undisplaced
What are types of fracture?
- simple or closed
- open
- transverse
- spiral
- impacted
- greenstick and torus
- comminuted
What are some abnormal stresses of normal bone?
- Overuse so stress exerted on bone is greater than bone capacity to remodel
- Bone weakening
- Stress fracture
- Risk of complete fracture
What are causes of abnormal stress?
- Weight baring bones - tibia, metatarsals, navicular
- Activity related: athletes, occupational, military, female, athlete triad
- Disorded eating, amenorrhea, osteoporosis
What does vitamin D deficiency cause?
- Osteomalacia
- Rickets
What does malignancy cause?
- Primary
- Bone metastases
What does osteoporosis cause?
Soft bone
What are different types of osteroperosis?
More common in females [Female:Male = 4:1]
Postmenopausal Osteoporosis – Women 50-70
Senile Osteoporosis - > 70
Secondary osteoporosis
When does osteoporosis and osteopenia happen?
If osteoclast activity > osteoblast activity -> Disrupted microarchitecture
When does secondary osteoporosis happen?
•Hypogonadism •Glucocorticoid excess •Alcoholism Associated with ‘fragility fractures’ – hip, spine, wrist Low energy trauma -> fracture
What scores are associated with osteopenia and osteoporosis?
Normal bone: T-score greater than -1
Osteopenia T-score -1 to -2.5
Osteoporosis T-score of -2.5 or less
What are some primary bone cancers?
- Osteosarcoma
- Chondrosarcoma
- Ewing sarcoma
- Chordoma
What primary malignant tumours metastasise to bone?
- Prostate: blastic
- Breast: lytic and blastic
- Kidney: lytic
- Thyroid: lytic
- Lung: lytic
What does blastic mean?
Building
What does lytic mean?
Break down
What is paediatric vitamin D deficiency?
- Before physis closure
- Rickets
What is adult vitamin D deficiency?
- After physis closure
- Osteromalacia
What is osteogenesis imperfecta?
‘Brittle Bone Disease’
Hereditary – autosomal dominant or recessive
Why could there be a decrease in type 1 collagen in osteogenesis imperfecta?
- Decreased secretion
* Production of abnormal collagen