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virals > Inhibit entry - drugs > Flashcards

Inhibit entry - drugs Flashcards

1
Q

CAMOSTAT

A
  • A orally available serine protease inhibitor
  • Inhibits the protein used by SARS-COV2 to enter
  • Prevents host cell entry

Protein inhibitor of IMPRSS2

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2
Q

What does IMPRSS2 do?

A
  • Activates the spike protein SARS-COV2

* Essential for viral spread in the lungs alongside host cell viral entry

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3
Q

APILIMOD

A

• pikFYVE inhibitor

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4
Q

What is pikFYVE

A
  • A lipid kinase involved in endosome maturation

* Believed to prevent viral invasion by inhibiting host cell proteases

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5
Q

What is the issue with APILIMOD?

A
  • It is believed that is blocks antiviral immune response

* Immunosuppression can be aggravated by APILIMOD

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virals (6 decks)

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