Inhibit entry - drugs Flashcards
1
Q
CAMOSTAT
A
- A orally available serine protease inhibitor
- Inhibits the protein used by SARS-COV2 to enter
- Prevents host cell entry
Protein inhibitor of IMPRSS2
2
Q
What does IMPRSS2 do?
A
- Activates the spike protein SARS-COV2
* Essential for viral spread in the lungs alongside host cell viral entry
3
Q
APILIMOD
A
• pikFYVE inhibitor
4
Q
What is pikFYVE
A
- A lipid kinase involved in endosome maturation
* Believed to prevent viral invasion by inhibiting host cell proteases
5
Q
What is the issue with APILIMOD?
A
- It is believed that is blocks antiviral immune response
* Immunosuppression can be aggravated by APILIMOD