Inherited Equine Disorders

Question 1

SCID

Answer 1

Severe combine immunodeficiency
Autosomal recessive in Arabians
Foals susceptible to infection and pneumonia as mother’s passive immunity wears off.
Lack of DNA-PKCS
DNA-protein kinase catalytic subunit

Question 2

Bleeders

Answer 2

Autosomal recessive
Exercise induced pulmonary bleeding form pounding of hooves damaging lungs and increasing pulmonary pressure.
Treatment: Lasix (diuretic)

Question 3

Wobblers syndrome

Answer 3

Cervical vertebrae malformation of C5, C6, C7.
Recessive
Thoroughbreds and quarter horses
Spinal cord compression

Question 4

Lethal white foal syndrome

Answer 4

Overo X Overo
Recessive mutation in endothelin receptor type B gene (EDNRB)
Aganglionosis: large intestine lacks nerves cells and doesn’t function
Causes early death