Inherited Cattle Disorders

Question 1

Cervical vertebral malfunction

Answer 1

Holsteins
Traced to single bull
Missense mutation in bovine SLC35A3

Question 2

Bovine Brachspina syndrome

Answer 2

Monogenic autosomal recessive
3.3 kb deletion on FANCI on chromosome 21
Shortened spine, skin, uneven teeth, malformed organs

Question 3

Bovine Leukocyte Adhesion Deficiency
(BLAD)

Answer 3

Autosomal recessive
Single Point mutation at 383 of CD18 gene
Traced to one bull
Infection, fever, low appetite, pneumonia, ulcers, stunted growth.

Question 4

Syndactlyly

Answer 4

Autosomal recessive and variable penetrance.
Holsteins and angus
2 independent mutations in bovine LRP4
Traced to one Holstein
Fusion of digits
Carriers have superior milk and fat

Question 5

Bovine progressive degenerative myeloencephalopathy (Weaver)

Answer 5

Autosomal recessive. Inbreeding
Brown Swiss
Single nucleotide polymorphism associated with nervous system genes
1) NRCAM
2) PNPPLA8
3) CTTNBP2
Causes hind leg weakness and abnormal reflexs. Wearing gait

Question 6

Tibial Hemimelia

Answer 6

Autosomal recessive
Shorthorn cattle
Fused joints, hernias, and skull deformity.

Question 7

Curly calf syndrome

Answer 7

Autosomal recessive
Angus
Traces to one ancestor
Causes curved spine, extended/contracted limbs, and thin

Question 8

Developmental duplication
(Polymelia)

Answer 8

Angus
Calves born with extra limbs
Can be caused by embryos environment.