Inhalers and related drugs Flashcards
MDI general information and instructions?
metered dose inhalers contain a hydrofluoroalkane propellant
• To use: shake 10 seconds → exhale fully → place inhaler one or two fingers from mouth → start inhaling as the button is pressed → finish inhalation → hold breath 10 seconds → exhale via nose → rinse mouth
DPI general info and instructions?
dry powder inhalers
• To use: exhale fully → make tight seal around inhaler → quick, deep inhale → hold breath 10 seconds → exhale via nose → rinse mouth
asthma definition?
inflammatory condition of the lungs caused by inflammatory mediators
inflammatory mediators?
histamine, leukotrienes, prostaglandins
bronchodilators vs. steroids:
- Use bronchodilator first, then steroid to treat underlying cause
- Inhaled bronchodilators; only treat symptoms
Beta-2 agonists details:
sympathomimetics
stimulate beta-2 receptors in the lungs → bronchodilaton
rescue inhaler details
- Onset of 5 minutes
* Metered dose inhalers; used QID
rescue inhaler generics?
albuterol, levalbuterol, pirbuterol class of all is beta-2 agonists
albuterol Trades?
Proventil HFA, Ventolin HFA, ProAir HFA
albuterol details?
beta-2 agonist
• Racemeic
• May have more side effects
levalbuterol Trade and details?
Xopenex HFA (quick relief, beta-2 agonist)
• R-isomer
• May have fewer side effects than albuterol
Xopenex generic?
levalbuterol
beta-2 agonist
Maxair generic and details?
pirbuterol (quick relief, beta-2 agonist)
Autohaler - breath activated MDI
pirbuterol Trade?
Maxair Autohaler
quick relief beta-2 agonist
long term control inhalers info?
beta-2 agonists (sympathomimetics)
• Indicated for asthma prophylaxis → will not relieve acute attack
• Dry powder inhalers
• BBW: increases risk of asthma related deaths in patients who use this alone instead of in combination with a steroid
long-term control Beta-2 generics?
salmeterol, indacaterol, formoterol
Serevent generic?
salmeterol
long acting beta-2 agonist
salmeterol Trade and details?
Serevent Diskus (long acting beta-2 agonist) • BID - DPI • Number on the top of the diskus means the number of doses remaining
Foradil generic?
formoterol
sympathomimetic - long acting
formoterol Trade and details?
Foradil Aerolizer (long acting b-2 agonist)
• BID - DPI
• Refrigerate in the pharmacy
• Can be kept at room temperature for 4 months by the patient
indacaterol Trade and details?
Arcapta NeoHaler (long acting b-2 agonist) qday -- DPI
Arcapta generic?
indacaterol
long acting b-2 agonist
anticholinergic bronchodilator details?
o Block cholinergic receptors in the lungs → blocks ACh → bronchodilation
o Indicated for asthma prophylaxis
o Side effect: xerostomia
anticholinergic bronchodilator generics?
ipratropium, tiotropium, aclidinium
ipratropium bromide + albuterol
ipratropium Trade and details?
Atrovent HFA (anticholinergic)
• QID
• MDI
tiotropium Trade and details?
Spiriva Handihaler (anticholinergic) • qday - long acting • DPI
aclidinium Trade and details?
Tudorza Pressair (anticholinergic) • BID - long acting • DPI
combination anticholinergic brochodilator generics?
albuterol, ipratropium bromide
combination bronchodilator Trade and details?
Combivent Respimat (albuterol, ipratropium bromide)
• MDI
• Rescue inhaler
• Contains soya lecithin; do not use if allergic to soy or peanuts
bronchodilators for nebulization details?
o Used in an updraft machine; drug diluted with normal saline
• Put solution for nebulization in machine → machine nebulizes liquid into a mist and patient breathes in with a mask for about 15 minutes
generics available for nebulization?
albuterol, levalbuterol, ipratropium, arformoterol, combo of albuterol and ipratropium
AccuNeb generic?
albuterol (nebulization)
QID
albuterol Trade for nebulization?
AccuNeb QID
Xopenex generic nebulization?
levalbuterol
QID
no Trade generic for nebulization?
ipratropium
QID
levalbuerol Trade for nebulization?
Xopenex solution for nebulization