Infrared Spectrophotometry- FTIR

Question 1

What is FTIR?

Answer 1

Fourier Transform Infrared Spectroscopy.

Question 2

What is FTIR used for?

Answer 2

To identify and characterise functional groups based on absorption of infrared light.

Question 3

NaCl
KBr
Diamond
Quartz cuvettes

Answer 3

Optical materials used in FTIR due to their transparency in infrared region.

KBr: used for solid samples
NaCl/KBr: used for liquid phase FTIR
Diamond: ATR setups (Attenuated Total Reflectance.)
Quartz cuvettes: used for NIR-FTIR in aqueous samples.

Question 4

Describe the process of FTIR?

Answer 4

A sample is exposed to infrared radiation.
Some infrared light is absorbed while some passes though.
The absorbed light causes bond vibrations that is converted to absorption spectrum with absorption peaks at unique wavelengths.

Question 5

What is NIR-FTIR?

MIR

Answer 5

Near Infrared - Fourier Transform Infrared Spectroscopy

Mid Infrared

Question 6

What drug is P-hydroxyacetanilide?

Answer 6

acetaminophen/paracetamol

Question 7

How can FTIR be used in analysis of P-hydroxyacetanilide

Answer 7

FTIR can detect different crystalline forms of paracetamol and identify formulations