Inflammatory Disorders Flashcards
Papulosquamous conditions
Psoriasis Atopic and contact dermatitis Seborrheic dermatitis Pityriasis rosea Lichen planus Drug eruptions
5 cardinal signs of psoriasis
Plaque Well-circumscribed Bright red colour Silvery scale Symmetric
Common places for plaque type psoriasis
Scalp
Elbows
Knees
Palms and soles
3 nail signs in psoriasis
Nail pitting
Lifting of the nail plate (onycholysis)
Oil drop sign
Types of psoriasis
Plaque type Guttate variant Inverse psoriasis Pustular psoriasis Erythrodermic psoriasis
What type of T cells are involved in
- Psoriasis
- Eczema
- Th1 or Th17
2. Th2
Atopic dermatitis
Eczema Ill defined margins, erythema Mostly on flexor surfaces Scale Can see lichenification
Seborrheic dermatitis
Commonly found on the scalp, eyebrows, around the ears, nasolabial folds, and can be on the trunk
Not well demarcated
Fine scale
Pityriasis rosea
Always on the trunk where the shirt is
Never involves the face and scalp
Plaques tend to be oval and follow the skin lines
Has Herald’s patch (first lesion, largest)
Fine scale within the plaque
5 P’s of lichen planus
Papules Polygonal (not true circles) Purple Planar (flat topped) Pruritic (can have excoriation)
Most common presentation of a drug eruption
Morbilliform rash
Combo of macules and papules
Bullous pemphigoid
Age > 60 years old Tense bullae Surrounding erythema Very itchy Antibodies are targeting antigens in the basement membrane
Pemphigus vulgaris
Age 40-60
Flaccid bullae
Erosions present
Oral mucosa often involved
Higher mortality rate that bullous pemphigoid
Antibodies target antigens in the stratum spinosum
Positive Nikolsky sign (skin will slough if you press on it)
Steven Johnson’s syndrome
Necrosis of epidermis Hemorrhagic crusted erosions Mucosal involvement Life threatening Mostly caused by medications Dark hemorrhagic crust on the lips is very classic
Toxic epidermal necrolysis
Necrosis of epidermis > 30% of body surface area involvement An extension of Steven Johnson's High mortality rate (heat loss, blood flow, infection) Have to be transported to a burn unit
