Inflammatory Disease of The Skin Flashcards
What are the two classifications of eczema?
Endogenous and exogenous
What is the genetic component of eczema?
Mutation on filaggrin chrom. 1
What are the types of endogenous eczema?
Atopic, seborrhoeic, discoid, varicose
What are the types of exogenous eczema?
Contact and photo reaction (due to allergy or drugs)
What blood levels are high in atopic eczema?
IgE
What type of hypersensitivity reaction is dermatitis?
Type IV
What are the different categories of hypersensitivity and an example of each
Type I - anaphylaxis
Type II - blood transfusion
Type III - serum sickness
Type IV - dermatitis
What is serum sickness?
A delayed (4-10 day) reaction to non-human protein
What are the complications of atopic eczema?
Bacterial infection - staph Viral infection - molluscum Tiredness Growth reduction Psychological impact
What is the management of atopic eczema?.
Emollients
Topical steroids
Bandages
Antibiotics
What are common allergens found in contact dermatitis?
Nickel
Chromate (cement)
Cobalt (dye)
What is seborrhoeic dermatitis?
Chronic scales skin condition which is often thought to be dandruff and is worse in HIV
What specific topical treatment can be used in seborrhoeic dermatitis?
Anti-yeast shampoo
What is venous dermatitis?
Dermatitis found on the skin overlying varicose veins
What is the definition of psoriasis?
A chronic relapsing and remitting skin condition which may appear at any age and affect any part of the skin
What causes psoriasis?
Tcell mediated autoimmune disease
What diseases is psoriasis linked to? (4)
Psoriatic arthritis
Metabolic syndrome
Liver disease / alcohol abuse
Depression
What are the types of psoriasis?
Plaque
Guttate
Pustular
Erythrodermic
How is psoriasis managed?
Topical creams Phototherapy Acitretin Methotrexate Ciclosporin Infliximab
What is Acitretin?
An oral retinoid
What topical therapies are used in psoriasis?
Moisturisers
Steroids
Retinoids
What are the features of pityriasis alba?
Dry rough skin in cheeks
Hypopigmenations
More common in non-Caucasians
What is the treatment for impetigo?
Topical antiseptic
Oral Abx - erythromycin
What are the features of mastocytosis?
Mast cells in skin
Wide spread ski inflammation
Mistaken for impetigo