inflammatory dermatoses Flashcards
DIAGRAM what does dermis contain
sweat gland (apocrine), sebaceous gland and hair follicles
structure of stratum corneum+ signfiicance of defect, including mutated protein
keratinocytes ie corneocytes held together by a lipid glue=barrier: defect (often in FILAGRIN gene)= eczema
atopic march
idea that hypersensitivites like eczema peak at a certian period of life (often as a child for eczema), then gradually get better
pathology of atopic eczema
genetic factors ie filagrin gene mutation and extrinsic factors ie allergens or infections cause acute eczema (CD4+ TH2 response), and chronic via IFN alpha (CD8+TH1)
sign of filagrin gene mutation
palmar hyperlinearity (lones of lines in palms)
feature of chronic eczema
LICHENIFICATION ie thickened skin with some redness
eczema herpeticum
often caused by herpes virus
eczema herpeticum
often caused by herpes virus
seborrhoeic eczema
caused by fungi eg dandruff on hair
discoid eczema
patches of eczema that look like coins
psoriasis with difference to eczema
red plaques, which look very different from normal skin (in eczema difference is less define)
psoriasis with difference to eczema
red plaques, which look very different from normal skin (in eczema difference is less define)
histology of psoriasis- features
hyperkeratosis (lots of them), parakeratosis (has nuclei as immature), acanthosis (thickened skin), and inflammation (would see inflammatory cells in epidermis)
nails in psoriasis
onycholysis (splittng of nail from bed), and pitting (small pits in nails)
guttate psoriasis
small pustules (small patches) often in back
palmoplantar pustulosis
small pustules in only palms and feet
generalised pustular psoriasis
lots of pustules all over skin
generalised pustular psoriasis
lots of pustules all over skin
features of acne
white heads (closed comedomes), blackheads (open comedomes), pustules+ papules, nodules (inflammatory lump)
bullous pemphigoid and epidermolysis bullosa- sticking at basement membrane and autoantibodies
tonofilaments/anchoring fibrils stick epidermis onto dermis at basement membrane- autoantibodies against protein involved eg BPAG1/2 prevent this sticking ie splitting of skin, causing DEEP BLISTERS
bullous pemphigoid- sticking at basemenet membrane and autoantibodies
tonofilaments/anchoring fibrils stick epidermis onto dermis at basement membrane- autoantibodies against protein involved eg BPAG1/2 prevent this sticking ie splitting of skin, causing BLISTERS
pempigus vulgaris and difference to bullous pemphigoid
autoantibodies against proteins connecting keratinocytes= SUPERFICIAL BLISTERS ie split in epidermis, NOT at basement mebrane
