inflammatory (class 4) Flashcards
what is the inflammatory response?
sequential reaction to cell injury. neutralizes and dilutes the inflammatory agent. removes necrotic materials. establishes an environment for healing and repair.
Acute inflammation?
healing in 2-3 weeks without residual damage, neutrophils are predominant WBC.
subacute inflammation?
lasts longer.
chronic inflammation?
lasts for weeks, months, or even years with persistent and repeated tissue injury, predominant BC are lympgs and macrophages. Ex. rheumatoid arthritis, osteomyelitis.
Local inflammation
pain, erythema, heat, edema, change in function
systemic inflammation
elevated T,P,R. increased WBC with shift to left, vascular response inflammatory mediators (histamine, prostaglandins, leukotriene) cause vasodilation & increase capillary permeability. cytokines cause fever.
wound classifications:
by cause: surgical or nonsurgical.
by duration: acute or chronic (>3months)
By depth of tissue affected: superficial (involves epidermis) partial thickness (wound extends into dermis) full thickness (involves subcutaneous tissue and may extend to fascia, muscle, tendon, or bone)
Regeneration:
replace lost tissue with same type (liver)
repair:
replace with connective tissue; various types.
primary intention:
type of healing that occurs when wound margins are approximated. ex. surgical inscisions.
initial phase
3-5 days, approximation, migration, fibrin meshwork.
granulation
5days-3weeks, fibroblasts, surface pink vascular, edges begin to regenerate and migrate.
mascarturation & scar contratction
collagen organized/remodeled avascualar scar forms.
secondary intention
type of healing for wounds that have large amounts of exudate, wide irregular margins and extensive tissue loss and edges cannot be approximated. wounds related to trauma, ulceration, and infection. inflammation is more significant. healing and granulation takes place from the edges inward and from the bottom upward; healing process life primary intention but more granulation and tissue scarring.
tertiary intention
wound contaminated or left open after infection to be sutured later after infection is controlled. healing occurs with delayed suturing of a wound. results in a larger and deeper scar.
Hemorrhage
hematoma- collection of blood under the tissues
infection
signs of infection early withing 2-3 days. surgical wound infection 4-5 days.