Inflammatory arthropathies - associated autoantibodies

Question 1

What is the key antibody associated with rheumatoid arthritis ?

Answer 1

Anti-CCP

Question 2

What are the majority of patients with ankylosing spondilitis positive for?

Answer 2

HLA-B27 90% are positive (although only a small majority who are positive develop spondylitis)

Question 3

What are the antibodies associated with SLE ?

Answer 3

• ANA (anti nuclear antibody)
• dsDNA (Anti-double stranded DNA antibody)
• Anti-Sm
• Anti-Ro, La and Anti-RNP
• C3/4 levels are low

Question 4

What is the best antibody for detecting SLE?

Answer 4

Anti-dsDNA

Question 5

What are the main antibodies associated with sjorgens syndrome ?

Answer 5

Anti-Ro and Anti-La antibodies

Question 6

What is the antibody associated with limited system sclerosis ?

Answer 6

Anti-centromere antibody

Question 7

What is the antibody associated with diffuse systemic sclerosis ?

Answer 7

Anti-Scl-70 antibody

Question 8

What antibody is associated with mixed connective tissue disease ?

Answer 8

Anti-RNP

Question 9

What are the antibodies associated with antiphospholipid syndrome ?

Answer 9

Anti-cardiolipin antibody and lupus anti-coagulant, anti-beta 2 glycoprotein

Question 10

What is the antibody which is unique to myositis (polymyositis and dermatomyositis)?

Answer 10

Anti-Jo-1

Question 11

What is the immunoglobulin associated with Henoch-Schonlein purpura?

Answer 11

IgA

Question 12

What are the ANCA associated vasculitis’s ?

Answer 12

GPA, EGPA, RLV, CSS

Question 13

What are the antibodies associated with GPA?

Answer 13

cANCA and PR3 (proteinase-3)

Question 14

What is the antibodies associated with EGPA and MPA?

Answer 14

MPO-ANCA