Inflammatory Flashcards

1
Q

rheumatoid types

A

seropositive

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2
Q

rheumatoid variants

A

seronegative

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3
Q

generalized connective tissue autoimmune disease involving synovial tissue resulting in polyarticular joint inflammation

A

RA

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4
Q

most common inflammatory arthritis

A

RA

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5
Q

what is the prevalence for RA

A

20-60 years - females > males

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6
Q

characterized by bilateral symmetry and progressive nature leading to deformity

A

RA

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7
Q

when testing, what is RA positive and negative for

A

(+) RA factor

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8
Q

severe joint disease/deformity

A

arthritis mutilans

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9
Q

enlargement of the gastrocnemius bursa

A

baker’s cyst

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10
Q

PIP flexion, DIP extension

A

boutonniere deformity

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11
Q

leukopenia, splenomegaly, RA

A

felty’s syndrome

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12
Q

soft tissue swelling at MCP

A

haygarth’s nodes

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13
Q

stiff joints after inactivity

A

jelling phenomena

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14
Q

accumulation of inflammatory cells, with necrotic area and fibrosis seen on extensor surfaces

A

rheumatoid nodule

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15
Q

flexion of DIP and extension of PIP

A

swan neck deformity

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16
Q

intermitten absence of the articular cortex due to erosion

A

dot-dash appearance

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17
Q

rat bite, pocket erosions localized loss of intra-articular cortex adjacent to the capsular insertion due to pannus erosion at the anatomical bare area

A

margina erosion

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18
Q

vascular granulation tissue that spreads over the intra-articular surfaces of the bone and cartilage

A

pannus

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19
Q

occular complications such as lacrimal gland atrophy which leads to dry eyes is characteristic of

A

RA

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20
Q

to be diagnosed with RA 4 of the following must be present

A
  • morning stiffness for at least 6 weeks
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21
Q

most common sites of involvement for RA

A

NAME?

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22
Q

a synovial cyst that extends into soft tissues posterior to the knee

A

baker’s cyst

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23
Q

most common cause of upper cervical neurological symptoms

A

atlanto-axial impaction from RA

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24
Q

where does RA erosion affect the dens

A

NAME?

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25
cranial settling is an effect of RA, what is it
#NAME?
26
still's disease
juvenile chronic arthritis (juvenile RA)
27
onset of RA at less than 16 years old
still's disease
28
loosely attached periosteum in children
periostisis
29
symptoms of JCA
hands - periostitis and shortening
30
generalized seropositive connective tissue disorder involving multiple organs, most common in females, elevated ESR and ANA positive
systemic lupus erythematosis (SLE)
31
butterfly rash
systemic lupus erythematosis (SLE)
32
most frequent and serious feature of SLE
kidney involvement leading to nephropathy and renal failure
33
administration of steroids as a treatment for SLE may lead to
#NAME?
34
radiographic changes of SLE
#NAME?
35
how does SLE affect the hands
#NAME?
36
how does SLE affect the spine
increase ADI in about 8.5%
37
disorder following rheumatic fever and multiple connective tissue disorders
jaccoud's arthropathy
38
antecedent strep. pharyngitis
jaccoud's arthropathy
39
transitory and migrating arthralgia, myalgia, weight loss and residual mitral valve disease
jaccoud's arthropathy
40
marked by non-erosive, reversible joint deformity
jaccoud's arthropathy
41
how does jaccoud's affect the hands and feet
#NAME?
42
generalized systemic inflammatory connective tissue disorder involving skin, lungs, GI tract, kidneys and musculoskeletal system
progressive systemic sclerosis
43
cutaneous manifestation of progressive systemic sclerosis
scleroderma
44
causes small vessel disease and fibrosis in multiple organ systems
progressive systemic sclerosis
45
three stages of skin appearance in progressive systemic sclerosis
#NAME?
46
puffy painful swelling in the extremities
progressive systemic sclerosis
47
a sympathetic nervous system dysfunction characterized by cyclic vascular changes usually of the hands which is precipitated by the cold or emotional upset
raynaud's phenomenon
48
components of CREST syndrome
#NAME?
49
what is SLAC
scaphoid-lunate advanced collapse
50
are most cases of JCA seropositive or seronegative
seronegative
51
is RA seropositive of seronegative
seropositive
52
scleroderma distribution to the chest
interstitial fibrosis
53
scleroderma distribution to the GI
smooth muscle dysfunction causing esophageal aperistalsis and reduced lower sphincter pressure
54
clinical features of CREST
#NAME?
55
chronic inflammatory disorder, predominately affecting young adults males primarily involves axial skeleton
ankylosing spondylitis (AS)
56
characterized by a sequela of articular ankylosis, ligamentous ossification and enthesopathic changes
AS
57
synonyms for AS
marie strumpell's disease and rhizomelic spondylitis
58
50% of AS patients will also have
peripheral disease especially of the hips and shoulders
59
most common seronegative spondyloarthropathy
AS
60
are females or males more likely to get AS
males 10:1
61
what does HLA-B27 have to do with AS
90% of people with AS are positive for HLA-B27
62
distribution of AS
#NAME?
63
clinical features of AS
#NAME?
64
management of AS
NSAIDS to limit joint inflammation and pain
65
sclerosis at the inferior aspect of the SI joint especially at the iliac aspect in post partum females
osteitis condensans ilii
66
where does AS target the spine
thoracolumbar and lumbosacral
67
joints involved in AS
#NAME?
68
roman's lesions
corner erosion of vertebral body (AS)
69
shiny corner sign
reactive sclerosis (AS)
70
vertebral squaring
loss of anterior concavity (AS)
71
bamboo spine
thin syndesmophytes (AS)
72
dagger sign
interspinous or supraspinous ligament ossification (AS)
73
trolley track sign
z joint capsular ossification (AS)
74
whiskering
ischial enthesopathy (AS)
75
andersson lesion
endplate destruction (AS)
76
carrot stick fracture
spinal fracture associated with AS
77
syndesmophytes imply
seronegative joint disease
78
vertically oriented spurs that represent the sequalae of inflammatory disease of the spinal ligaments. they are ossification of the outer fibers of the annulus and the inner fibers of the ALL
syndesmophytes
79
syndesmophytes that are thicker and non marginal indicate
#NAME?
80
syndesmophytes that are thinner and marginal indicate
#NAME?
81
if there is ossification on the anterior portion of the vertebral bodies but you are unsure if it is seronegative, what do you need
HLA-B27 test
82
osteophytes are more horizontal as syndesmophytes are more
horizontal
83
arthritis associated with gut sidorders, usually ulcerative colitis and regional enteritis (crohn's disease)
enteropathic arthritis
84
asymmetrical small joint involvement (hands) mostly DIPs. mediated by immune system
psoriatic arthritis
85
mouse ears appearance
peripheral erosions with periostitis (psoriatic arthritis)
86
pencial and cup appearance
central erosion (psoriatic arthritis)
87
ray pattern
when the distribution is more prominent along one digit than across joint type (psoriatic arthritis)
88
which types of syndesmophytes are associated with psoriatic arthritis
non-marginal
89
reactive arthritis
reiter's disease
90
some symptoms and causative factors of reiter's
#NAME?
91
arthritis occurring in association with genitourinary or gastrointestinal infections
reiter's syndrome
92
where is reiter's most commonly located
lower extremity (calcaneus)
93
classic triad of reiter's syndrome
#NAME?
94
how is reiter's syndrome differentiated with psoriatic arthritis
psoriatic - nail pitting, psoriatic plaques
95
lover's heel
reiter's
96
arthropathy characterized by intra-articular deposition of calcium pyrophosphate crystals
calcium pyrophosphate deposition disease
97
CPPD
calcium pyrophosphate deposition disease
98
synonyms for CPPD
#NAME?
99
may mimic gout during acute flare
CPPD
100
most common location for CPPD
affinity for joints containing menisci
101
DJD at an unusual location should raise suspicion of
CPPD
102
an inherited disorder that causes the body to absorb and store too much iron
hemochromatosis
103
most common genetic disorder in the USA
hemochromatosis
104
gout is which type of joint disease
metabolic
105
a sodium urate induced arthropathy
gout
106
disorder of purine metabolism principally in males
gout
107
most common location for gout
MTP of first toe
108
chronic gout
tophi