Inflammatory Flashcards

1
Q

rheumatoid types

A

seropositive

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2
Q

rheumatoid variants

A

seronegative

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3
Q

generalized connective tissue autoimmune disease involving synovial tissue resulting in polyarticular joint inflammation

A

RA

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4
Q

most common inflammatory arthritis

A

RA

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5
Q

what is the prevalence for RA

A

20-60 years - females > males

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6
Q

characterized by bilateral symmetry and progressive nature leading to deformity

A

RA

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7
Q

when testing, what is RA positive and negative for

A

(+) RA factor

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8
Q

severe joint disease/deformity

A

arthritis mutilans

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9
Q

enlargement of the gastrocnemius bursa

A

baker’s cyst

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10
Q

PIP flexion, DIP extension

A

boutonniere deformity

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11
Q

leukopenia, splenomegaly, RA

A

felty’s syndrome

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12
Q

soft tissue swelling at MCP

A

haygarth’s nodes

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13
Q

stiff joints after inactivity

A

jelling phenomena

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14
Q

accumulation of inflammatory cells, with necrotic area and fibrosis seen on extensor surfaces

A

rheumatoid nodule

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15
Q

flexion of DIP and extension of PIP

A

swan neck deformity

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16
Q

intermitten absence of the articular cortex due to erosion

A

dot-dash appearance

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17
Q

rat bite, pocket erosions localized loss of intra-articular cortex adjacent to the capsular insertion due to pannus erosion at the anatomical bare area

A

margina erosion

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18
Q

vascular granulation tissue that spreads over the intra-articular surfaces of the bone and cartilage

A

pannus

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19
Q

occular complications such as lacrimal gland atrophy which leads to dry eyes is characteristic of

A

RA

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20
Q

to be diagnosed with RA 4 of the following must be present

A
  • morning stiffness for at least 6 weeks
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21
Q

most common sites of involvement for RA

A

NAME?

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22
Q

a synovial cyst that extends into soft tissues posterior to the knee

A

baker’s cyst

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23
Q

most common cause of upper cervical neurological symptoms

A

atlanto-axial impaction from RA

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24
Q

where does RA erosion affect the dens

A

NAME?

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25
Q

cranial settling is an effect of RA, what is it

A

NAME?

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26
Q

still’s disease

A

juvenile chronic arthritis (juvenile RA)

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27
Q

onset of RA at less than 16 years old

A

still’s disease

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28
Q

loosely attached periosteum in children

A

periostisis

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29
Q

symptoms of JCA

A

hands - periostitis and shortening

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30
Q

generalized seropositive connective tissue disorder involving multiple organs, most common in females, elevated ESR and ANA positive

A

systemic lupus erythematosis (SLE)

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31
Q

butterfly rash

A

systemic lupus erythematosis (SLE)

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32
Q

most frequent and serious feature of SLE

A

kidney involvement leading to nephropathy and renal failure

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33
Q

administration of steroids as a treatment for SLE may lead to

A

NAME?

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34
Q

radiographic changes of SLE

A

NAME?

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35
Q

how does SLE affect the hands

A

NAME?

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36
Q

how does SLE affect the spine

A

increase ADI in about 8.5%

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37
Q

disorder following rheumatic fever and multiple connective tissue disorders

A

jaccoud’s arthropathy

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38
Q

antecedent strep. pharyngitis

A

jaccoud’s arthropathy

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39
Q

transitory and migrating arthralgia, myalgia, weight loss and residual mitral valve disease

A

jaccoud’s arthropathy

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40
Q

marked by non-erosive, reversible joint deformity

A

jaccoud’s arthropathy

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41
Q

how does jaccoud’s affect the hands and feet

A

NAME?

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42
Q

generalized systemic inflammatory connective tissue disorder involving skin, lungs, GI tract, kidneys and musculoskeletal system

A

progressive systemic sclerosis

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43
Q

cutaneous manifestation of progressive systemic sclerosis

A

scleroderma

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44
Q

causes small vessel disease and fibrosis in multiple organ systems

A

progressive systemic sclerosis

45
Q

three stages of skin appearance in progressive systemic sclerosis

A

NAME?

46
Q

puffy painful swelling in the extremities

A

progressive systemic sclerosis

47
Q

a sympathetic nervous system dysfunction characterized by cyclic vascular changes usually of the hands which is precipitated by the cold or emotional upset

A

raynaud’s phenomenon

48
Q

components of CREST syndrome

A

NAME?

49
Q

what is SLAC

A

scaphoid-lunate advanced collapse

50
Q

are most cases of JCA seropositive or seronegative

A

seronegative

51
Q

is RA seropositive of seronegative

A

seropositive

52
Q

scleroderma distribution to the chest

A

interstitial fibrosis

53
Q

scleroderma distribution to the GI

A

smooth muscle dysfunction causing esophageal aperistalsis and reduced lower sphincter pressure

54
Q

clinical features of CREST

A

NAME?

55
Q

chronic inflammatory disorder, predominately affecting young adults males primarily involves axial skeleton

A

ankylosing spondylitis (AS)

56
Q

characterized by a sequela of articular ankylosis, ligamentous ossification and enthesopathic changes

A

AS

57
Q

synonyms for AS

A

marie strumpell’s disease and rhizomelic spondylitis

58
Q

50% of AS patients will also have

A

peripheral disease especially of the hips and shoulders

59
Q

most common seronegative spondyloarthropathy

A

AS

60
Q

are females or males more likely to get AS

A

males 10:1

61
Q

what does HLA-B27 have to do with AS

A

90% of people with AS are positive for HLA-B27

62
Q

distribution of AS

A

NAME?

63
Q

clinical features of AS

A

NAME?

64
Q

management of AS

A

NSAIDS to limit joint inflammation and pain

65
Q

sclerosis at the inferior aspect of the SI joint especially at the iliac aspect in post partum females

A

osteitis condensans ilii

66
Q

where does AS target the spine

A

thoracolumbar and lumbosacral

67
Q

joints involved in AS

A

NAME?

68
Q

roman’s lesions

A

corner erosion of vertebral body (AS)

69
Q

shiny corner sign

A

reactive sclerosis (AS)

70
Q

vertebral squaring

A

loss of anterior concavity (AS)

71
Q

bamboo spine

A

thin syndesmophytes (AS)

72
Q

dagger sign

A

interspinous or supraspinous ligament ossification (AS)

73
Q

trolley track sign

A

z joint capsular ossification (AS)

74
Q

whiskering

A

ischial enthesopathy (AS)

75
Q

andersson lesion

A

endplate destruction (AS)

76
Q

carrot stick fracture

A

spinal fracture associated with AS

77
Q

syndesmophytes imply

A

seronegative joint disease

78
Q

vertically oriented spurs that represent the sequalae of inflammatory disease of the spinal ligaments. they are ossification of the outer fibers of the annulus and the inner fibers of the ALL

A

syndesmophytes

79
Q

syndesmophytes that are thicker and non marginal indicate

A

NAME?

80
Q

syndesmophytes that are thinner and marginal indicate

A

NAME?

81
Q

if there is ossification on the anterior portion of the vertebral bodies but you are unsure if it is seronegative, what do you need

A

HLA-B27 test

82
Q

osteophytes are more horizontal as syndesmophytes are more

A

horizontal

83
Q

arthritis associated with gut sidorders, usually ulcerative colitis and regional enteritis (crohn’s disease)

A

enteropathic arthritis

84
Q

asymmetrical small joint involvement (hands) mostly DIPs. mediated by immune system

A

psoriatic arthritis

85
Q

mouse ears appearance

A

peripheral erosions with periostitis (psoriatic arthritis)

86
Q

pencial and cup appearance

A

central erosion (psoriatic arthritis)

87
Q

ray pattern

A

when the distribution is more prominent along one digit than across joint type (psoriatic arthritis)

88
Q

which types of syndesmophytes are associated with psoriatic arthritis

A

non-marginal

89
Q

reactive arthritis

A

reiter’s disease

90
Q

some symptoms and causative factors of reiter’s

A

NAME?

91
Q

arthritis occurring in association with genitourinary or gastrointestinal infections

A

reiter’s syndrome

92
Q

where is reiter’s most commonly located

A

lower extremity (calcaneus)

93
Q

classic triad of reiter’s syndrome

A

NAME?

94
Q

how is reiter’s syndrome differentiated with psoriatic arthritis

A

psoriatic - nail pitting, psoriatic plaques

95
Q

lover’s heel

A

reiter’s

96
Q

arthropathy characterized by intra-articular deposition of calcium pyrophosphate crystals

A

calcium pyrophosphate deposition disease

97
Q

CPPD

A

calcium pyrophosphate deposition disease

98
Q

synonyms for CPPD

A

NAME?

99
Q

may mimic gout during acute flare

A

CPPD

100
Q

most common location for CPPD

A

affinity for joints containing menisci

101
Q

DJD at an unusual location should raise suspicion of

A

CPPD

102
Q

an inherited disorder that causes the body to absorb and store too much iron

A

hemochromatosis

103
Q

most common genetic disorder in the USA

A

hemochromatosis

104
Q

gout is which type of joint disease

A

metabolic

105
Q

a sodium urate induced arthropathy

A

gout

106
Q

disorder of purine metabolism principally in males

A

gout

107
Q

most common location for gout

A

MTP of first toe

108
Q

chronic gout

A

tophi