Inflammation/ Pain Quiz Flashcards
To be therapeutic something must be..
conducive to the healing process
Modality
Application of some form of stress to the body for the purpose to eliciting an adaptive response
Primary Trauma
Immediate cellular destruction due to the trauma. Irreversible.
Secondary Trauma
Cell death caused by blockage of oxygen supply to the injured area
Phases of Healing: Phase 1: Inflammatory Response
Chemical messengers elicit local and systemic effects, cells remove debris and cells create groundwork for repair/ regeneration.
0-4 days
Phases of Healing: Phase 2: Fibroblastic Repair Phase
Cells restore vascular and structural integrity of injured structures
2 days-6 weeks
Phases of Healing: Phase 3: Maturation Remodeling Phase
Healed tissue adapt to functional loading
3 weeks to 2 years
The Healing Process
One big continuum; the phases overlap with no distinct beginning or end points
Immediate Response to Injury
Vasoconstriction. Norepinephrin limits blood loss
Vasodilation
Occurs due to release of chemical mediators (histamine and leukotaxin)
Cardinal Signs
heat, redness, swelling, pain, loss of function
Leukocytes
Neutrophils, eosinophil, basophils and lymphocytes
Jobs of Leukocytes
move to the endothelial lining, line to endothelium in a tight formation, leukocytes adhere around cell walls, draw to injured sites, begin process of phagocytosis
Platelets
Adhere to one another; a mechanical plug
Clotting Cascade
Permanent stop of blood from injured area
Fibrin Patch
Forms the blood clot of scab; covered injured tissue
Fibroblastic Repair
Starts around 48-72 hours post injury and can last for 6 weeks
Fibroblastic Repair: Granulation Phase
growth of new tissue, development of new blood vessels, and development of fibrous tissues
Fibroblastic Repair: Fibroblastic Phase
As the fibrin clot begins to break down, a connective tissue matrix forms. Acceleration of laying down collagen. The wound contracts and begins to form the collagen matrix. The scar that is formed during this phase is pink, weak and immature
Maturation Remodeling Phase
Begins 3 weeks after injury and can last for up to 2 years. Scarred, smoother skin. Type III collagen is replaced with stronger Type I collagen
Chronic Inflammation
Inflammatory process lasting longer than a month
What can cause chronic inflammation?
Autoimmune causes and extended acute inflammation from repetitive trauma
In tissue with a higher metabolic activity wound closure would occur in..
5-8 days
Repair
Tissue heals with a scar
Regeneration
Actual tissue is replaced
Hyaline Cartilage healing
Little capacity to heal
Peripheral Nerves
Cannot regenerate after they have died. Cannot regenerate from partial tearing.
The closer a nerve injury is to the cell body….
the less likely it will heal