Inflammation Glossary Flashcards
Phospholipases [L1]
Degrade phospholipids in the cell membrane
Cytochrome c [L1]
Leakage promotes apoptosis and in mitochondria aids in oxidative phosphorylation and energy production
ATPases [L1]
Hastens ATP depletion
Proteases [L1]
Breaks down membrane and cytoskeleton proteins
Endonucleases [L1]
DNA and chromatin fragmentation
Catalse, superoxide dismutases, glutathione peroxidase s [L1]
Enzymes which decrease injury caused by free radicals
p38 MAP kinase, Jun N-terminal kinase [L1]
Stress kinases, initiate signalling cascades that co-ordinate a cell’s response to damage
p53 [L1]
senses DNA damage and halts cell division or induces apoptosis
BMF [L1]
Response to damage to actin cytoskeleton
Bim [L1]
Response to microtubule damage
Bad [L1]
Response to inadequate stimulation by growth factors
Mitochondrial permeability transition [L1]
Formation of nonselective high-conductance channels remocing the transmembrane potential required for oxidative phosphorylation
Lipid Peroxidation [L1]
Attack of double bonds in unsaturated fatty acids in membranes
Glycation [L1]
Addition of sugar residues on proteins
Ubiquitin-proteasome pathway [L1]
Induces cellular protein destruction ]